Men with low levels of DHEA in the blood run an increased risk of developing coronary heart disease events. The Sahlgrenska Academy study has been published in the Journal of the American College of Cardiology.
The term prohormone refers to the precursor of a hormone. DHEA is a prohormone that is produced by the adrenal glands and can be converted to active sex hormones. While the tendency of DHEA levels to fall with age was discovered long ago, the biological role of the prohormone is largely unknown.
Åsa Tivesten, Professor at the University of Gothenburg
University of Gothenburg
Researchers at Sahlgrenska Academy, University of Gothenburg, have now shown that elderly men with low levels of DHEA in the blood run an increased risk of developing coronary heart disease events.
Lower level - greater risk
The study—which monitored 2,614 men age 69-80 in Gothenburg, Uppsala and Malmö for five years—assessed DHEA levels. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up.
“Endogenous production of DHEA appears to be a protective factor against coronary heart disease,” says Åsa Tivesten, who coordinated the study. “High DHEA levels may also be a biomarker of generally good health in elderly men.”
According to Professor Claes Ohlsson, "While the study establishes a clear correlation between DHEA in the blood and coronary heart disease, the discovery does not indicate whether or not treatment with DHEA will reduce the risk in individual patients."
“Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men” was published in the Journal of the American College of Cardiology on October 28.
Link to article: http:// http://content.onlinejacc.org/article.aspx?articleid=1918789
Åsa Tivesten, Professor at the Sahlgrenska Academy and the Wallenberg Laboratory, University of Gothenburg
Phone: +46 31-3422913
Cell: +46 73-8005250
Approximately 1.4 million Swedes are estimated to have coronary heart disease. The condition is the most common cause of death in the country. Coronary heart disease patients live an average of 12-15 years longer than they did only 30 years ago.
—Swedish Heart-Lung Foundation
Henrik Axlid | idw - Informationsdienst Wissenschaft
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences