An international research group including Viennese pathologist Lukas Kenner has reviewed cases of possible association between breast implants and a form of lymphoma that may develop tumours at a later stage.
The researchers conclude that breast implants can cause a new subtype of the rare yet malignant lymphoma known as ALCL. The research results have been published in the journal Mutation Research.
Worldwide there have been 71 documented cases of patients with anaplastic large cell lymphoma (ALCL) in which researchers suspected breast implants to be the cause. ALCL is normally found in the lymph nodes, as well as in skin, lung, liver and soft tissue, but not usually in the breast.
Cases in which ALCL developed in the breast region almost exclusively involved patients who have had breast surgery. In these cases, ALCL developed around ten years after the operation. The tumours grew in the scar tissue around the implant.
Breast implants are generally safe and studies have found no association between breast surgery and other forms of cancer. ALCL itself is also an extremely rare occurrence. Among three million breast implants, there are between one and six reported cases of ALCL.
ALCL is divided into two subtypes. In one subtype, the cancerous cells produce an abnormal form of the protein ALK (anaplastic lymphoma kinase). The other type does not express ALK in tumour cells at all. While patients with ALK-positive lymphoma have a better chance of survival, the cancer is considerably more aggressive in ALK-negative cases.
Implant-related ALCL appears to form a third group. The cells do not express ALK, but patients have good survival rates. “This is a previously unrecognized, new subtype of ALCL,” Lukas Kenner explains. “We must now determine the exact causes behind its occurrence.”
The search for causes
The actual reasons why implants can cause lymphoma remain unclear. While some patients were successfully treated with chemotherapy and radiation therapy, the lymphoma in many cases subsided on its own following removal of the implant and the surrounding tissue. An abnormal immune response from the body could therefore be a cause of the cancer. Kenner and his team are now preparing for further studies in which implants and dentures will be examined in other parts of the body.
Lukas Kenner from the Medical University Vienna, the University of Veterinary Medicine, Vienna and the Ludwig Boltzmann Institute for Cancer Research cooperated for this study with scientists from Cambridge, Liverpool, Swansea and Australia. The project was funded by the British organisation Leukaemia & Lymphoma Research.
The article „Anaplastic large cell lymphoma (ALCL) and breast implants: Breaking down the evidence” by Xuan Ye, Kayvan Shokrollahi, Warren M. Rozen, Rachel Conyers, Penny Wright, Lukas Kenner, Suzanne D. Turner and Iain S. Whitaker was published in the Journal Mutation Research. DOI: 10.1016/j.mrrev.2014.08.002
About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. www.vetmeduni.ac.at
Prof. Lukas Kenner
University of Veterinary Medicine Vienna (Vetmeduni Vienna), Medical University Vienna, Ludwig Boltzmann Institute
T +43 664 1188385
Science Communication / Public Relations
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1153
Dr. Susanna Kautschitsch | idw - Informationsdienst Wissenschaft
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
21.02.2017 | Earth Sciences
21.02.2017 | Medical Engineering
21.02.2017 | Trade Fair News