Researchers, led by Dr Kristine Lain at the University of Kentucky, USA, compared 30 pregnant women, who developed GDM later in pregnancy, with 29 pregnant women who did not develop GDM, as controls. Levels of the hormone, adiponectin, were measured from blood samples taken during the first trimester of pregnancy, at an average of 9 weeks gestation.
Adiponectin measurements were then grouped into quartiles, and the highest quartile used as a reference. All patients underwent routine screening for GDM in the second trimester of pregnancy at 24-28 weeks. Logistic regression analysis was used to assess the odds of developing GDM based on adiponectin concentration.First trimester adiponectin levels were significantly lower in women who went on to develop GDM (4.3 ± 0.4 µg/ml) compared to the control group (6.9 ± 0.6 µg/ml). Normal pregnancy adiponectin concentration is approximately 7 ± 0.8 µg/ml. Women with adiponectin levels in the lowest quartile (
Adiponectin has insulin sensitising properties, and protects against metabolic syndrome and related conditions that can lead to type 2 diabetes. Decreased levels of adiponectin are associated with an increased risk of developing type 2 diabetes, in healthy, non-pregnant individuals. Studies on adiponectin levels in GDM patients have, until now, been limited. This study shows for the first time that adiponectin concentrations are reduced as early as nine weeks into pregnancy in patients with gestational diabetes. Such changes could contribute to patients’ lifelong risk of developing type 2 diabetes, and also lead to an earlier diagnosis of GDM. This study now needs to be repeated in a larger cohort of women, with the goal of measuring adiponectin levels in the pre-pregnancy state, ultimately to determine if the low adiponectin/high GDM risk group can be identified pre-pregnancy.
Researcher Dr Kristine Lain said:
“Gestational diabetes, if untreated, leads to increased risk of neonatal complications such as excess growth, jaundice, and respiratory problems. In addition, GDM places women at an increased risk of developing type 2 diabetes later in life. We already know that adiponectin levels are reduced in gestational diabetes patients later in pregnancy, but our results show that women with gestational diabetes have detectable metabolic differences at nine weeks of gestation, much earlier than the current clinical diagnosis. At this stage of pregnancy, most women who develop gestational diabetes have normal glucose tolerance, so lower adiponectin concentrations could act as an early indicator for gestational diabetes. Using adiponectin, we may be able to predict quite early in pregnancy who is at risk of developing gestational diabetes. Our study is based on a relatively small group of women, and the role of adiponectin as a predictor of gestational diabetes now needs to be assessed in a larger cohort of patients. Although further research is needed to determine the exact relationship between adiponectin levels and glucose tolerance during pregnancy, our results suggest adiponectin levels may be an early useful marker of gestational diabetes.”
Adiponectin is a hormone released from fat cells into the bloodstream, where it plays a role in regulating glucose levels and insulin sensitivity, and protects against the umbrella of conditions that can lead to the development of type 2 diabetes. GDM can usually be treated by dietary control, but sometimes insulin may need to be taken. Women with GDM have a 30-50% risk of developing type 2 diabetes during their lifetime, compared to a 10% risk in healthy individuals.
Rebecca Dixon | alfa
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology