Researchers, led by Dr Kristine Lain at the University of Kentucky, USA, compared 30 pregnant women, who developed GDM later in pregnancy, with 29 pregnant women who did not develop GDM, as controls. Levels of the hormone, adiponectin, were measured from blood samples taken during the first trimester of pregnancy, at an average of 9 weeks gestation.
Adiponectin measurements were then grouped into quartiles, and the highest quartile used as a reference. All patients underwent routine screening for GDM in the second trimester of pregnancy at 24-28 weeks. Logistic regression analysis was used to assess the odds of developing GDM based on adiponectin concentration.First trimester adiponectin levels were significantly lower in women who went on to develop GDM (4.3 ± 0.4 µg/ml) compared to the control group (6.9 ± 0.6 µg/ml). Normal pregnancy adiponectin concentration is approximately 7 ± 0.8 µg/ml. Women with adiponectin levels in the lowest quartile (
Adiponectin has insulin sensitising properties, and protects against metabolic syndrome and related conditions that can lead to type 2 diabetes. Decreased levels of adiponectin are associated with an increased risk of developing type 2 diabetes, in healthy, non-pregnant individuals. Studies on adiponectin levels in GDM patients have, until now, been limited. This study shows for the first time that adiponectin concentrations are reduced as early as nine weeks into pregnancy in patients with gestational diabetes. Such changes could contribute to patients’ lifelong risk of developing type 2 diabetes, and also lead to an earlier diagnosis of GDM. This study now needs to be repeated in a larger cohort of women, with the goal of measuring adiponectin levels in the pre-pregnancy state, ultimately to determine if the low adiponectin/high GDM risk group can be identified pre-pregnancy.
Researcher Dr Kristine Lain said:
“Gestational diabetes, if untreated, leads to increased risk of neonatal complications such as excess growth, jaundice, and respiratory problems. In addition, GDM places women at an increased risk of developing type 2 diabetes later in life. We already know that adiponectin levels are reduced in gestational diabetes patients later in pregnancy, but our results show that women with gestational diabetes have detectable metabolic differences at nine weeks of gestation, much earlier than the current clinical diagnosis. At this stage of pregnancy, most women who develop gestational diabetes have normal glucose tolerance, so lower adiponectin concentrations could act as an early indicator for gestational diabetes. Using adiponectin, we may be able to predict quite early in pregnancy who is at risk of developing gestational diabetes. Our study is based on a relatively small group of women, and the role of adiponectin as a predictor of gestational diabetes now needs to be assessed in a larger cohort of patients. Although further research is needed to determine the exact relationship between adiponectin levels and glucose tolerance during pregnancy, our results suggest adiponectin levels may be an early useful marker of gestational diabetes.”
Adiponectin is a hormone released from fat cells into the bloodstream, where it plays a role in regulating glucose levels and insulin sensitivity, and protects against the umbrella of conditions that can lead to the development of type 2 diabetes. GDM can usually be treated by dietary control, but sometimes insulin may need to be taken. Women with GDM have a 30-50% risk of developing type 2 diabetes during their lifetime, compared to a 10% risk in healthy individuals.
Rebecca Dixon | alfa
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences