Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Levels of key hormone during first trimester of pregnancy could lead to earlier diagnosis of gestational diabetes

08.10.2008
New research shows women who develop diabetes during pregnancy (gestational diabetes mellitus) have reduced levels of an insulin-sensitive hormone, adiponectin, as early as nine weeks into the pregnancy. The findings, published in the latest edition of Clinical Endocrinology, show early warning signs of gestational diabetes (GDM) are evident months before the clinical diagnosis is currently made (20-22 weeks).

Researchers, led by Dr Kristine Lain at the University of Kentucky, USA, compared 30 pregnant women, who developed GDM later in pregnancy, with 29 pregnant women who did not develop GDM, as controls. Levels of the hormone, adiponectin, were measured from blood samples taken during the first trimester of pregnancy, at an average of 9 weeks gestation.

Adiponectin measurements were then grouped into quartiles, and the highest quartile used as a reference. All patients underwent routine screening for GDM in the second trimester of pregnancy at 24-28 weeks. Logistic regression analysis was used to assess the odds of developing GDM based on adiponectin concentration.

First trimester adiponectin levels were significantly lower in women who went on to develop GDM (4.3 ± 0.4 µg/ml) compared to the control group (6.9 ± 0.6 µg/ml). Normal pregnancy adiponectin concentration is approximately 7 ± 0.8 µg/ml. Women with adiponectin levels in the lowest quartile (

Adiponectin has insulin sensitising properties, and protects against metabolic syndrome and related conditions that can lead to type 2 diabetes. Decreased levels of adiponectin are associated with an increased risk of developing type 2 diabetes, in healthy, non-pregnant individuals. Studies on adiponectin levels in GDM patients have, until now, been limited. This study shows for the first time that adiponectin concentrations are reduced as early as nine weeks into pregnancy in patients with gestational diabetes. Such changes could contribute to patients’ lifelong risk of developing type 2 diabetes, and also lead to an earlier diagnosis of GDM. This study now needs to be repeated in a larger cohort of women, with the goal of measuring adiponectin levels in the pre-pregnancy state, ultimately to determine if the low adiponectin/high GDM risk group can be identified pre-pregnancy.

Researcher Dr Kristine Lain said:

“Gestational diabetes, if untreated, leads to increased risk of neonatal complications such as excess growth, jaundice, and respiratory problems. In addition, GDM places women at an increased risk of developing type 2 diabetes later in life. We already know that adiponectin levels are reduced in gestational diabetes patients later in pregnancy, but our results show that women with gestational diabetes have detectable metabolic differences at nine weeks of gestation, much earlier than the current clinical diagnosis. At this stage of pregnancy, most women who develop gestational diabetes have normal glucose tolerance, so lower adiponectin concentrations could act as an early indicator for gestational diabetes. Using adiponectin, we may be able to predict quite early in pregnancy who is at risk of developing gestational diabetes. Our study is based on a relatively small group of women, and the role of adiponectin as a predictor of gestational diabetes now needs to be assessed in a larger cohort of patients. Although further research is needed to determine the exact relationship between adiponectin levels and glucose tolerance during pregnancy, our results suggest adiponectin levels may be an early useful marker of gestational diabetes.”

General Information
GDM results when maternal blood glucose levels increase, and the body cannot produce enough insulin to cope with the elevated glucose levels. The high glucose levels can cross the placenta and lead to increased growth of the baby, which can then cause a difficult delivery. GDM also increases the mother’s risk of developing pre-eclampsia, high blood pressure during pregnancy. Risk factors for developing GDM include obesity, a family history of type 2 diabetes, and previous GDM.

Adiponectin is a hormone released from fat cells into the bloodstream, where it plays a role in regulating glucose levels and insulin sensitivity, and protects against the umbrella of conditions that can lead to the development of type 2 diabetes. GDM can usually be treated by dietary control, but sometimes insulin may need to be taken. Women with GDM have a 30-50% risk of developing type 2 diabetes during their lifetime, compared to a 10% risk in healthy individuals.

Rebecca Dixon | alfa
Further information:
http://www.endocrinology.org

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>