Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Laboratory for Molecular Exercise Physiology at Mainz University is up and running

08.02.2011
Specialists at Johannes Gutenberg University Mainz, Germany develop tests to detect gene doping and individual exercise concepts for therapeutic purposes as well as for popular sports and for high-performance athletes

The specialists for Sports Medicine at Johannes Gutenberg University Mainz (JGU are already in the starting blocks: Their ambitious objective is to develop a routine test for gene doping in time for the London Olympic Games in 2012. With the completion of the new Laboratory for Molecular Exercise Physiology on the JGU campus in January 2011, they are now ready to start working on this and other projects.

Professor Perikles Simon, specialist in sports medicine and neuroscientist, came to Mainz University in 2009 as director of the Division of Sports Medicine, Prevention, and Rehabilitation. Working in close collaboration with his former colleagues in Tübingen, Simon developed a test that uses conventional blood samples to provide conclusive proof of gene doping. The process was presented in September 2010, and applications have been submitted for the relevant international patents. There was previously no practicable method that could be used to determine whether an athlete had undergone doping using EPO or other genes. Indeed, it was thought that there was no way a corresponding test could be developed. It is not yet clear to what extent athletes are already using gene transfer as a method of enhancing performance. Over the year 2011, the World Anti-Doping Agency (WADA) will be contributing more than half a million US dollars to the project to develop a routine test for gene doping, which may be available in time for the next Olympic Games.

With the Laboratory for Molecular Exercise Physiology now on track, the field of Sports Medicine at Mainz University will increasingly be focusing on aspects of customized diagnostics and treatment. This is a new approach that takes individual personal circumstances into account when it comes to tailoring exercise to the demands of mass and professional sports, and, more particular even, to the stringent requirements of therapeutic applications. To this end, JGU's Sports Medicine and the University Medical Center Mainz are planning close collaboration - starting in projects on colon cancer, autoimmune disorders, and psychological disorders. "Exercise increases levels of free circulating DNA in the blood - a circumstance that may help us for improve diagnostics" explains Professor Simon. The participating researchers hope that they will not only be able to improve the reliability of diagnostic tests for primary disorders, but also to better adapt adjuvant sport and exercise therapy concepts to the needs of individual patients. "Patients respond differently to sport and exercise; in some cases, the outcome is very good. But others do not respond at all or even experience deterioration of their status." The idea is to use molecular diagnostics in order to predict what adjuvant therapy approach is likely to be most beneficial. As it becomes possible to directly account for more and more blood parameters, popular and high-performance sport will be revolutionized: it may even be possible to develop sophisticated analytical techniques that can show whether a further intensification of training will result in improvement of performance or not.

For their work on molecular biology and genetics, Simon and his team have one biosafety level BSL 1 laboratory and four BSL 2 genetic technology laboratories at their disposal. JGU is thus one of the few universities in Germany equipped to carry out molecular and genetic research in sports medicine. The construction costs amounting to 1.2 million Euros were granted under the second phase of the "Knowledge Creates Future" program of Rhineland-Palatinate. Furthermore, research projects in the field of Sports Medicine are sponsored by groups such as the Dr Gerhard and Martha Röttger Foundation and the Kalkhof-Rose Foundation. In developing the gene doping test, Mainz University's Division of Sports Medicine is collaborating with the University Hospital in Tübingen, Germany and with the International Center for Genetic Engineering and Biotechnology (ICGEB) in Trieste in Italy.

Petra Giegerich | idw
Further information:
http://www.uni-mainz.de/eng/14021.php

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>