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New knowledge about bone marrow transplants can help leukemia patients

Acute lymphatic leukemia is the most common form of blood cancer in children. Even though chemotherapy is improving, the cancer often returns.

Johan Jansson's research at Kalmar University in Sweden shows that cancer cells that have been exposed to chemotherapy and survived are less vulnerable to chemotherapy, and more aggressive as well.

But this research also yielded discoveries that should be able to enhance our treatment of the disease.

Johan Jansson's research shows that leukemia cells that have been exposed to chemotherapy and survived did not develop resistance against bone marrow transplants from a sibling, for example. At the same time, however, several important changes were observed in these cancer cells. On the one hand, they were less vulnerable to chemotherapy and, on the other, their growth rate increased.

Johan Jansson also identified several immunologically important genes that either increased or decreased when they had been exposed to a bone marrow transplant. Three of these genes were especially interesting in that they were involved in activating the immune defense and the killing of cancer cells. It was also shown that such a bone marrow transplant could have an inhibiting effect on the leukemia cells that also proved to be able to activate parts of the immune defense.

Finally, Johan Jansson studied whether it is possible to check the leukemia cells that remain after a bone marrow transplant. This was done by vaccinating mice with a mixture of 'dead' leukemia cells and immune cells from a donor. It was observed that the immune defense was activated to some degree, but that the mice did not live any longer as a result. On the other hand, it was seen that these mice had B cells that produced antibodies against leukemia cells. This knowledge could be further elaborated to develop and enhance the effects of a bone marrow transplant.

Thesis directors: Prof. Craig A. Mullen, University of Rochester, NY, USA; Prof. Sven Tågerud, Kalmar University, Sweden.

Deputy director: Prof. Kristina Nilsson Ekdahl, Kalmar University.

External examiner: Prof. Mikael Sigvardsson, Linköping University, Sweden

Johan Jansson can be reached at or phone: +1-585-719-5562 and through October 6 at cell phone: +46-73 3988792

Sven Tågerud can be reached at, phone: +46 (0)480-44 62 56.

Pressofficer Karolina Ekstrand;; +46-766476 030

Karolina Ekstrand | idw
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