Johan Jansson's research at Kalmar University in Sweden shows that cancer cells that have been exposed to chemotherapy and survived are less vulnerable to chemotherapy, and more aggressive as well.
But this research also yielded discoveries that should be able to enhance our treatment of the disease.
Johan Jansson's research shows that leukemia cells that have been exposed to chemotherapy and survived did not develop resistance against bone marrow transplants from a sibling, for example. At the same time, however, several important changes were observed in these cancer cells. On the one hand, they were less vulnerable to chemotherapy and, on the other, their growth rate increased.
Johan Jansson also identified several immunologically important genes that either increased or decreased when they had been exposed to a bone marrow transplant. Three of these genes were especially interesting in that they were involved in activating the immune defense and the killing of cancer cells. It was also shown that such a bone marrow transplant could have an inhibiting effect on the leukemia cells that also proved to be able to activate parts of the immune defense.
Finally, Johan Jansson studied whether it is possible to check the leukemia cells that remain after a bone marrow transplant. This was done by vaccinating mice with a mixture of 'dead' leukemia cells and immune cells from a donor. It was observed that the immune defense was activated to some degree, but that the mice did not live any longer as a result. On the other hand, it was seen that these mice had B cells that produced antibodies against leukemia cells. This knowledge could be further elaborated to develop and enhance the effects of a bone marrow transplant.
Thesis directors: Prof. Craig A. Mullen, University of Rochester, NY, USA; Prof. Sven Tågerud, Kalmar University, Sweden.
Deputy director: Prof. Kristina Nilsson Ekdahl, Kalmar University.
External examiner: Prof. Mikael Sigvardsson, Linköping University, Sweden
Johan Jansson can be reached at email@example.com or phone: +1-585-719-5562 and through October 6 at cell phone: +46-73 3988792
Sven Tågerud can be reached at firstname.lastname@example.org, phone: +46 (0)480-44 62 56.
Pressofficer Karolina Ekstrand; email@example.com; +46-766476 030
Karolina Ekstrand | idw
Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications
Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine