Because the concept of permanent neurological injury has given way to recognition of the brain’s potential for long-term regeneration ad reorganization, rehabilitations strategies are undergoing radical changes. The potential for five new translational interventions was examined in an article published ahead of print on November 13 by Neurology Clinical Practice: Barrett AM, Oh-Park M, Chen P, Ifejika NL: Five New Things in Neurorehabilitation. doi: 10.1212/01.CPJ.0000437088.98407.fa. Drs. Barrett, Oh-Park and Chen are affiliated with Kessler Foundation. Dr. Ifejika is with the University of Texas Medical School at Houston.
Medical resources are limited, so it is important to focus on areas of greatest potential, according to Dr. Barrett, and strive for advances that translate to effective treatments in the shortest possible timeframes. An emphasis on experience-dependent learning is advised, as well as biological techniques that induce a permissive state for the development of new, optimal, functional brain activation patterns. “The five treatments we identified are based on behavioral (1, 2, 3), or non-invasive physiological stimulation (4, 5),” said Dr. Barrett. “While these have been explored primarily in stroke rehabilitation, they are potentially applicable to other neurological conditions such as brain injury, spinal cord injury and multiple sclerosis.”
Constraint-induced movement therapy, and other intensive, experience-dependent learning, may improve rehabilitation outcomes in people with hemiparesis from stroke and other brain disorders.
Prism adaptation therapy, and therapies using virtual feedback and implicitly integrating 3-D motor and perceptual function, may improve function in spatial neglect.Transcranial magnetic stimulation may induce a permissive brain state therapeutic for depression and promoting better motor and cognitive recovery.
Transcranial direct current stimulation might promote better mood, motor and cognitive rehabilitation outcomes, and has an appealing risk/cost profile for feasible future implementation.
Funding: Supported by Kessler Foundation (AMB, MO-P, PC), the National Institutes of Health (R01NS 055808 and K24HD062647: PI Barrett) and the Department of Education (NIDRR grant H133G120203).
About Stroke Rehabilitation Research at Kessler Foundation
Research studies span all domains of post-stroke cognitive dysfunction, but emphasize hidden disabilities after stroke, including hidden disabilities of functional vision (spatial bias and spatial neglect). Students, resident physicians, and post-doctoral trainees are mentored in translational neuroscience of rehabilitation. Dr. Barrett and her colleagues work closely with the clinical staff at Kessler Institute for Rehabilitation. Among their collaborative efforts are the founding of the Network for Spatial Neglect and development of the Kessler Foundation Neglect Assessment Process (KF-NAPTM). Stroke Research receives funding from the Department of Education/NIDRR; the National Institutes of Health/NICHD/NCMRR; Kessler Foundation; the Healthcare Foundation of New Jersey; and the Wallerstein Foundation for Geriatric Improvement. Scientists have faculty appointments at Rutgers New Jersey Medical School.
About A.M. Barrett, MD
A.M. Barrett, MD, a cognitive neurologist and clinical researcher, is director of Stroke Rehabilitation Research at Kessler Foundation, as well as chief of Neurorehabilitation Program Innovation at Kessler Institute for Rehabilitation. Her focus is brain-behavior relationships from the perspectives of cognitive neurology, cognitive neuroscience, and cognitive neurorehabilitation. Dr. Barrett is an expert in hidden cognitive disabilities after stroke, which contribute to safety problems & rehospitalization, increased caregiver burden, & poor hospital-to-home transition. She is a founder of the Network for Spatial Neglect, which promotes multidisciplinary research for this underdiagnosed hidden disability. Dr. Barrett is also professor of physical medicine & rehabilitation at Rutgers New Jersey Medical School and adjunct professor of neurology at Columbia University School of Medicine. She is a former president of the American Society for Neurorehabilitation.
Dr. Barrett is author of the reference article Spatial Neglect on emedicine.com. A recent publication is Barrett AM. Picturing the body in spatial neglect: descending a staircase. Neurology. 2013 Oct 8;81(15):1280-1.About Kessler Foundation
Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that seeks to improve cognition, mobility and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. For more information, visit KesslerFoundation.org.
Carolann Murphy, PA; 973.324.8382; CMurphy@KesslerFoundation.org
Lauren Scrivo, 973.324.8384/973.768.6583 (cell); LScrivo@KesslerFoundation.org
Carolann Murphy | EurekAlert!
Scientists develop tiny tooth-mounted sensors that can track what you eat
22.03.2018 | Tufts University
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Trade Fair News
22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences