Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Keeping track to selenium metabolism

Spanish and Danish researchers have developed a method for the in vivo study of the unknown metabolism of selenium, an essential element for living beings. The technique can help clarify whether or not it possesses the anti-tumour properties that have been attributed to it and yet have not been verified through clinical trials.

"It is vox populi that doctors around the world recommend selenium supplements to complement traditional therapy against cancer and the AIDS virus but the truth is that the basics of these properties are not clear," explains to SINC Justo Giner, a chemist from the University of Oviedo (Spain).

"Even the general metabolism of selenium has not been completely cleared up," adds Giner who, along with other researchers at the same university and the University of Pharmaceutical Sciences of Copenhagen (Denmark), has developed a new methodology for discovering how this element moves around living organisms. The study has been published in the March issue of the 'Analytical and Bioanalytical Chemistry' journal.

The in vivo study was carried out on laboratory rats, which were administered a stable metabolic tracer of enriched selenium (77Se). According to the researcher, "it opens the door for transferring this method to clinical trials on humans given that innocuous, non-radioactive isotopes are used."

In line with expected findings, the results reveal that selenium concentrations in biological tissue, blood and urine samples can indeed be analysed. Therefore, mass spectrometry techniques are employed along with a second isotopic tracer (74Se), which helps to quantify "with unequivocal precision" infinitesimal amounts of selenium in its different chemical forms that are distributed by the body.

Selenium is an antioxidant and plays an important role in the body's immune response. Understanding the path that it takes from the moment it is administered to when it is excreted could help to clarify its metabolism and its possible protecting effect against cancer and HIV.

The ideal dose of selenium

The main sources of selenium come from foods such as yeasts, animal products (meat, seafood, dairy products) and vegetables like broccoli, wheat-germ, nuts (especially Brazil nuts), oats, garlic and barley. The current recommended daily intake of selenium is approximately 55 micrograms for women and 70 micrograms for men.

Selenium deficiency is associated with different pathologies like endemic cardiomyopathy, cystic fibrosis, multiple sclerosis, rheumatoid arthritis, haemolysis and muscular dystrophy. Furthermore, thyroid metabolism is affected by selenium levels since the glands deiodinasa enzymes are in fact selenoproteins.

In contrast though, when intake is higher than nutritional requirements, selenium is considered a 'nutraceutical'. Mainly thanks to its antioxidant properties this means that it is beneficial for the health as long as it does not surpass the threshold in which it starts to become toxic.


Kristoffer Lunøe, Justo Giner Martínez-Sierra, Bente Gammelgaard, J. Ignacio García Alonso. "Internal correction of spectral interferences and mass bias for selenium metabolism studies using enriched stable isotopes in combination with multiple linear regression". Analytical and Bioanalytical Chemistry 402 (9): 2749�, March 2012. Doi: 10.1007/s00216-012-5747-7.

SINC | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital

nachricht Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>