Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Jortani among researchers finding new markers for acute kidney injury


Saeed A. Jortani, Ph.D., associate clinical professor in the University of Louisville’s Department of Pathology and Laboratory Medicine, headed up one of three labs in the United States involved in determining two new markers for acute kidney injury (AKI). The research group’s paper, “Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication,” was posted online this week by the American Journal of Respiratory and Critical Care Medicine.

AKI has been difficult to diagnose and treat early because current markers for it don’t show up until several hours after it has begun. The research group, however, validated two new markers – tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) – in urine that, when assessed together, give clinicians the ability to detect and begin treating AKI much earlier than the current standards.

Saeed Jortani, Ph.D.

Saeed Jortani, Ph.D.

The Jortani Clinical Trials Laboratories (JCTL) at UofL were among the independent labs that tested the results of the trial. The other two were at the University of California-San Diego and ARUP Laboratories, Salt Lake City, Utah.

The JCTL is certified under the Clinical Laboratories Improvement Amendments (CLIA) of the Centers for Medicaid & Medicare Services. As a CLIA-certified lab, the JCTL has undergone a rigorous review of its facilities and processes to ensure quality in the laboratory testing and analyses it provides.

AKI was formerly known as acute renal failure. It is an abrupt loss of kidney function, usually occurring within 48 hours or less. It can occur after serious infections, major surgery or taking certain medications. In its most serious form, it can cause the patient to require dialysis and can result in death. Groups at greatest risk for AKI are the elderly, men and African Americans.

Other institutions participating in the study were AGH Nephrology Associates, Durham VA Medical Center, Eastern Idaho Medical Consultants LLC, George Washington University, Hennepin County Medical Center, The International Heart Institute of Montana, Loma Linda University, Louisiana State University-Shreveport, The Methodist Hospital, Montefiore Medical Center, Northwestern University, Portland VA Medical Center, Rochester General Medicine, Stat'Tech Services LLC, Summa Health System Akron City Hospital, Tampa General Hospital, University of California, Los Angeles, University of California, San Diego, University of Chicago, University of Florida, University of Maryland, University of Michigan, University of Pittsburgh Medical Center, University of Utah, Vanderbilt University and Virginia Commonwealth University.

Jill Scoggins | EurekAlert!

Further reports about: AKI Loma acute kidney injury function injury markers metalloproteinases urine

More articles from Health and Medicine:

nachricht Older patients recover more slowly from concussion
06.10.2015 | Radiological Society of North America

nachricht Fatty liver disease and scarring have strong genetic component
02.10.2015 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists shrink particle accelerator

Prototype demonstrates feasibility of building terahertz accelerators

An interdisciplinary team of researchers has built the first prototype of a miniature particle accelerator that uses terahertz radiation instead of radio...

Im Focus: Simple detection of magnetic skyrmions

New physical effect: researchers discover a change of electrical resistance in magnetic whirls

At present, tiny magnetic whirls – so called skyrmions – are discussed as promising candidates for bits in future robust and compact data storage devices. At...

Im Focus: High-speed march through a layer of graphene

In cooperation with the Center for Nano-Optics of Georgia State University in Atlanta (USA), scientists of the Laboratory for Attosecond Physics of the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität have made simulations of the processes that happen when a layer of carbon atoms is irradiated with strong laser light.

Electrons hit by strong laser pulses change their location on ultrashort timescales, i.e. within a couple of attoseconds (1 as = 10 to the minus 18 sec). In...

Im Focus: Battery Production: Laser Light instead of Oven-Drying and Vacuum Technology

At the exhibition BATTERY + STORAGE as part of WORLD OF ENERGY SOLUTIONS 2015 in Stuttgart, the Fraunhofer Institutes for Laser Technology ILT and for Ceramic Technologies and Systems IKTS will be showing how laser technology can be used to manufacture batteries both cost- and energy-efficiently.

In the truest sense, it’s all about watts at the Dresden-based Fraunhofer Institute for Ceramic Technologies and Systems IKTS and the Aachen-based Fraunhofer...

Im Focus: New Sinumerik features improve productivity and precision

EMO 2015, Hall 3, Booth E06/F03

  • Drive optimization called automatically by the part program boosts productivity
  • Automatically switching the dynamic values to rapid traverse and interpolation...
All Focus news of the innovation-report >>>



Event News

EHFG 2015: Securing healthcare and sustainably strengthening healthcare systems

01.10.2015 | Event News

Conference in Brussels: Tracking and Tracing the Smallest Marine Life Forms

30.09.2015 | Event News

World Alzheimer`s Day – Professor Willnow: Clearer Insights into the Development of the Disease

17.09.2015 | Event News

Latest News

Graphene teams up with two-dimensional crystals for faster data communications

06.10.2015 | Information Technology

Laser-wielding physicists seize control of atoms' behavior

06.10.2015 | Physics and Astronomy

Flipping molecular attachments amps up activity of CO2 catalyst

06.10.2015 | Life Sciences

More VideoLinks >>>