Saeed A. Jortani, Ph.D., associate clinical professor in the University of Louisville’s Department of Pathology and Laboratory Medicine, headed up one of three labs in the United States involved in determining two new markers for acute kidney injury (AKI). The research group’s paper, “Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication,” was posted online this week by the American Journal of Respiratory and Critical Care Medicine.
AKI has been difficult to diagnose and treat early because current markers for it don’t show up until several hours after it has begun. The research group, however, validated two new markers – tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) – in urine that, when assessed together, give clinicians the ability to detect and begin treating AKI much earlier than the current standards.
Saeed Jortani, Ph.D.
The Jortani Clinical Trials Laboratories (JCTL) at UofL were among the independent labs that tested the results of the trial. The other two were at the University of California-San Diego and ARUP Laboratories, Salt Lake City, Utah.
The JCTL is certified under the Clinical Laboratories Improvement Amendments (CLIA) of the Centers for Medicaid & Medicare Services. As a CLIA-certified lab, the JCTL has undergone a rigorous review of its facilities and processes to ensure quality in the laboratory testing and analyses it provides.
AKI was formerly known as acute renal failure. It is an abrupt loss of kidney function, usually occurring within 48 hours or less. It can occur after serious infections, major surgery or taking certain medications. In its most serious form, it can cause the patient to require dialysis and can result in death. Groups at greatest risk for AKI are the elderly, men and African Americans.
Other institutions participating in the study were AGH Nephrology Associates, Durham VA Medical Center, Eastern Idaho Medical Consultants LLC, George Washington University, Hennepin County Medical Center, The International Heart Institute of Montana, Loma Linda University, Louisiana State University-Shreveport, The Methodist Hospital, Montefiore Medical Center, Northwestern University, Portland VA Medical Center, Rochester General Medicine, Stat'Tech Services LLC, Summa Health System Akron City Hospital, Tampa General Hospital, University of California, Los Angeles, University of California, San Diego, University of Chicago, University of Florida, University of Maryland, University of Michigan, University of Pittsburgh Medical Center, University of Utah, Vanderbilt University and Virginia Commonwealth University.
Jill Scoggins | EurekAlert!
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy