Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Japanese researchers show that acupuncture can improve skeletal muscle atrophy

25.04.2012
Team hopes findings will bolster practice’s reputation as a nonpharmacolgical treatment
A team of Japanese researchers will reveal study results Monday at the Experimental Biology 2012 meeting that show how acupuncture therapy mitigates skeletal muscle loss and holds promise for those seeking improved mobility through muscle rejuvenation.

"It is my hope that this study will demonstrate acupuncture's feasibility with regard to improving health among the elderly and medical patients. Our findings could identify acupuncture as the primary nonpharmacological treatment to prevent skeletal muscle atrophy in the future," says Akiko Onda, an acupuncturist and graduate student at the Waseda University School of Sport Sciences, who has been conducting a series of studies on skeletal muscle atrophy for the past four years. Her presentation will be at 12:25 p.m. Monday, April 23, at the American Society for Biochemistry and Molecular Biology annual meeting, which is part of EB2012.

Loss of skeletal muscle mass has a profound effect on the ability of the elderly and the sick to engage in physical activity. Because skeletal muscle has high plasticity, interventions such as exercise training, improved nutrition and mechanical stimulation are often recommended to prevent atrophy. Unfortunately, these can be challenging goals for those who are already frail or who have severe medical conditions. Onda insists an alternative nonpharmacological intervention is urgently required, and so she and her collaborators in two labs at Waseda University decided to explore how acupuncture affects skeletal muscle at the molecular level.

"The main focus of this study is changes in the mRNA expression levels of muscle-specific atrophic genes such as atrogin-1," Onda says. "Muscle mass and structure are determined by the balance between protein degradation and synthesis."

The team showed that decreases in muscle mass in mice and in the mRNA expression level of the E3 ubiquitin ligase atrogin-1 can be significantly reversed by acupuncture.

In spite of the World Health Organization's endorsement of acupuncture and the widespread use of acupuncture as a treatment for various diseases, acupuncture is still regarded by many as obscure and suspicious, and its underlying molecular mechanisms are almost completely unknown.

"Our results have uncovered one molecular mechanism responsible for the efficacy of acupuncture treatment and clarified its usefulness in preventing skeletal muscle atrophy in mice," Onda said. "We hope to introduce acupuncture as a new strategy for preventing skeletal muscle atrophy in the future. Further investigations into its molecular mechanisms will help to decrease the medical community's suspicion of acupuncture and provide us with a better understanding of how acupuncture treatment prevents skeletal muscle atrophy."

About the researchers

Akiko Onda, Graduate School of Sport Sciences, Minamisawa/Fukubayashi laboratories
Qibin Jiao, Ph.D., research associate of Faculty of Science and Engineering, Minamisawa laboratory
Susumu Minamisawa, professor of Faculty of Science and Engineering, corresponding author
Toru Fukubayashi, professor of Faculty of Sport Sciences, Fukubayashi laboratory

About Experimental Biology 2012

Experimental Biology is an annual gathering of six scientific societies that this year is expected to draw 14,000-plus independent scientists and exhibitors. The American Association of Anatomists (AAA) is a co-sponsor of the meeting, along with the American Physiological Society (APS), American Society for Biochemistry and Molecular Biology (ASBMB), American Society for Investigative Pathology (ASIP), American Society for Nutrition (ASN) and the American Society for Pharmacology and Experimental Therapeutics (ASPET).

More information about EB2011 for the media can be found on the press page: http://experimentalbiology.org/EB/pages/Press-Registration.aspx.

About the American Society for Biochemistry and Molecular Biology

The ASBMB is a nonprofit scientific and educational organization with more than 12,000 members worldwide. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, at nonprofit research institutions and in industry. The Society's student members attend undergraduate or graduate institutions. For more information about ASBMB, visit www.asbmb.org.
Contact: Angela Hopp
ahopp@asbmb.org
713-471-4541
American Society for Biochemistry and Molecular Biology

waseda university | Research asia research news
Further information:
http://www.waseda.jp
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>