Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Irregular arm swing may point to Parkinson's disease

Irregular arm swings while walking could be an early sign of Parkinson's disease, according to neurologists who believe early detection may help physicians apply treatments to slow further brain cell damage until strategies to slow disease progression are available.

Parkinson's disease is an age-related disorder involving loss of certain types of brain cells and marked by impaired movement and slow speech.

"The disease is currently diagnosed by tremors at rest and stiffness in the body and limbs," said Xuemei Huang, associate professor of neurology, Penn State Hershey College of Medicine. "But by the time we diagnose the disease, about 50 to 80 percent of the critical cells called dopamine neurons are already dead."

Huang and her colleagues are studying gait, or the manner in which people walk, to understand the physical signs that might be a very early marker for the onset of Parkinson's. They have confirmed Huang's clinical impression that in people with Parkinson's, the arm swing is asymmetrical. In other words, one arm swings much less than the other as a person walks.

"We know that Parkinson's patients lose their arm swing even very early in the disease but nobody had looked using a scientifically measured approach to see if the loss was asymmetrical or when this asymmetry first showed up," said Huang. Her team's findings appear in the current issue of Gait and Posture. "Our hypothesis is that because Parkinson's is an asymmetrical disease, the arm swing on one arm will be lost first compared to the other."

The researchers compared the arm swing of 12 people diagnosed three years earlier with Parkinson's, to eight people in a control group. The Parkinson's patients were asked to stop all medication the night before to avoid influencing the test results.

The team used special equipment to measure movement accurately, including many reflective markers on the study participants and eight digital cameras that captured the exact position of each segment of the body during a walk.

"Images from the cameras were sent to a computer where special software analyzed the data" explained Huang. "When a person walks, the computer was able to calculate the degree of swing of each arm with millimeter accuracy."

Analysis of the magnitude of arm swing, asymmetry and walking speed revealed that the arm swing of people with Parkinson's has remarkably greater asymmetry than people in the control group -- one arm swung significantly less than the other in the Parkinson's patients.

When the participants walked at a faster speed, the arm swing increased but the corresponding asymmetry between them remained the same.

"We believe this is the first demonstration that asymmetrical arm swings may be a very early sign of the disease," said Huang.

While slightly irregular arm swing occurs in people without Parkinson's, the asymmetry is significantly larger in those suffering from the disease.

"Our data suggests that this could be a very useful tool for the early detection of Parkinson's," noted Huang. "There are wide scale efforts to find drugs that slow cell death. When they are found, they could be used in conjunction with this technique to arrest or perhaps cure the disease because they could be given before great damage has occurred."

Other researchers in the study include Michael D. Lewek, assistant professor of exercise and sport science; Roxanne Poole, study coordinator; Julia Johnson, clinical fellow, and Omar Halawa, medical student, all at University of North Carolina.

The National Institutes of Health and the University of North Carolina Center for Human Movement Sciences funded this work. Penn State has filed a provisional patent application on behalf of the scientists.

Amitabh Avasthi | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>