AURORA, the first international molecular screening programme for metastatic breast cancer, presented at IMPAKT Breast Cancer Conference
While research has made great strides in recent decades to improve and significantly extend the lives of patients with early breast cancer, the needs of patients with advanced or metastatic disease have largely been ignored.
Moreover, despite the fact that the overall breast cancer death rate has dropped steadily over the last decade and significant improvements in survival have been made, metastatic breast cancer represents the leading cause of death among patients with the disease.
In this context the Breast International Group (BIG) recently launched AURORA, which will use molecular screening to improve our understanding of metastatic breast cancer and its response or lack of response to available drug therapies. In total 1300 women and men from about 60 hospitals in 15 European countries are expected to take part in the programme. Over time, BIG hopes to expand the programme well beyond Europe to involve several 1000 more patients.
Dr Martine Piccart-Gebhart, Chair of BIG and Director of the Medicine Department of the Institut Jules Bordet, strongly believes in this research programme and says: "It is almost unethical that we continue to treat women with metastatic breast cancer when we have so little knowledge of their disease. We now have powerful technologies for investigating the molecular landscape of tumours, and we have an obligation to women to establish AURORA as a large translational research effort that can hopefully lead to more effective treatments in the future".
Within AURORA, metastatic and primary breast cancer tissue specimens will be collected and screened with a panel of more than 400 cancer-related genes for the first time on a large scale. Plasma and blood samples will also be collected, and any samples not analysed immediately will be stored in an independent bio-repository to enable future research. An innovative bioinformatics platform has been developed to support the collection of AURORA data. These data are being collected in a way that will allow sharing and collaborating in the context of other initiatives started by researchers in North America.
AURORA will enable scientists to understand both why breast cancer metastasises and why some patients respond poorly to standard treatment, while others respond very well. Whenever possible, patients participating in AURORA will be offered to participate in a clinical trial testing new and promising drugs that target the specific genetic characteristics of their tumours. The ultimate hope is that AURORA will benefit patients by leading us to both better treatments and to finding cures for the women and men affected by this disease.
AURORA is made possible in part by generous grants from the Breast Cancer Research Foundation (BCRF), the Fondation Cancer (Luxembourg), the National Lottery (Belgium), NIF Trust, and individual donors.
-- About Breast International Group (BIG) --
The Breast International Group (BIG) is a non-profit organisation for academic breast cancer research groups from around the world, with its headquarters in Brussels, Belgium. Founded by leading European opinion leaders in 1999, BIG now constitutes a network of 49 collaborative groups based in Europe, Canada, Latin America, Asia and Australasia. These entities are tied to several thousand specialised hospitals and research centres worldwide. About 30 clinical trials are run or are under development under the BIG umbrella at any one time. BIG also works closely with the US National Cancer Institute (NCI) and the North American Breast Cancer Group (NABCG), so that together they act as a strong integrating force in the breast cancer research arena.
BIG facilitates and accelerates international breast cancer research by stimulating cooperation between its members and other academic networks, and collaborating with, but working independently from, the pharmaceutical industry. Large-scale cooperation is crucial to make significant advances in breast cancer research, reduce unnecessary duplication of effort, and optimally serve those affected by the disease. http://www.BIGagainstbreastcancer.org
-- About Martine Piccart-Gebhart --
Martine Piccart-Gebhart, MD, PhD is Professor of Oncology at the Université Libre de Bruxelles (ULB) and Director of the Medicine Department at the Institut Jules Bordet, Belgium. She is also co-founder and chair of the Breast International Group.
Dr Piccart-Gebhart is a member of numerous professional organisations, currently serving as President of the European CanCer Organisation (ECCO). She is immediate Past-President of the European Society for Medical Oncology (ESMO). From 2006 to 2009 she served as President of the European Organisation for Research and Treatment of Cancer (EORTC) and member of the American Society of Clinical Oncology (ASCO) board.
She has served as first author or co-author of about 400 scientific publications in peer-reviewed journals. She has received numerous awards in recognition of her achievements in the clinical research field, including the Jill Rose Award (New York), the William L. McGuire Award (San Antonio), the Umberto Veronesi Award for the Future Fight against Cancer (Cancun) and, recently, ASCO's David A. Karnofsky Memorial Award (Chicago).
-- About IMPAKT Breast Cancer Conference --
Jointly organised by BIG and the European Society for Medical Oncology (ESMO), the sixth edition of the IMPAKT Breast Cancer Conference will figure out how to best develop and better individualise new strategies to fight against breast cancer, putting current and future issues into perspective. In recent years, translational research in breast cancer has evolved at such a fast pace that it has made all believe that our dream of truly personalised medicine in breast cancer might soon become a reality. However, despite some advances, there are still many research goals to be achieved.
Having laboratory discoveries translated into clinical practice is what patients need, but it is equally important that data collected in the clinic get back to researchers to allow them to dig more deeply into the biological behaviour of the disease. Around 450 attendees are expected from throughout Europe and the rest of the world. http://www.impakt.org
-- IMPAKT Media registration --
BIG and ESMO welcome media interested in obtaining information and reporting on cancer issues. Registration is free to bona fide journalists on presentation of a letter of assignment and a valid press card. To register for the event, please complete Media Registration Form at http://www.impakt.org (Press & Media section).
-- Media contacts --
For questions about AURORA and BIG
Communications Manager, Breast International Group (BIG)
Mobile phone: +41 79 478 02 38
For questions about IMPAKT and ESMO
Press Officer, European Society for Medical Oncology (ESMO)
Mobile phone: +41 79 935 60 73
Cecilia Waldvogel | Eurek Alert!
Nanotubes are beacons in cancer-imaging technique
23.05.2016 | Rice University
More light on cancer
20.05.2016 | Lomonosov Moscow State University
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene
In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...
The trend-forward world of display technology relies on innovative materials and novel approaches to steadily advance the visual experience, for example through higher pixel densities, better contrast, larger formats or user-friendler design. Fraunhofer ISC’s newly developed materials for optics and electronics now broaden the application potential of next generation displays. Learn about lower cost-effective wet-chemical printing procedures and the new materials at the Fraunhofer ISC booth # 1021 in North Hall D during the SID International Symposium on Information Display held from 22 to 27 May 2016 at San Francisco’s Moscone Center.
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
25.05.2016 | Trade Fair News
25.05.2016 | Life Sciences
25.05.2016 | Power and Electrical Engineering