Clinical pharmacologists at Heidelberg University Hospital have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed for the first time that interactions between drugs can be detected with minute doses in the range of nanograms.
In the published study, the team investigated the interaction between the sedative midazolam, which is metabolized in the liver by the protein cytochrome P450 3A, and the fungicide ketoconazole, a well-known inhibitor of this cytochrome. The inhibition of the cytochrome and, in turn, the reduced degradation of midazolam, were already precisely measured in the nanogram dose. This interaction in particular plays an important role for patients who need to take several drugs simultaneously. Many drugs inhibit this enzyme, which metabolises around half of all regularly used medicines. However, if a drug is degraded too slowly, at normal doses, it accumulates in the body and, in the worst case, can cause toxicity.
Dr. Annette Tuffs | idw
Further reports about: > Interaction between water and forest > Mass spectrometry > Medical Wellness > Pharmacoepidemiology > contamination in drinking water > drug combination > environmental toxin > fungicide ketoconazole > mass spectrometer > metabolic enzymes > nanogram > pharmacology > ultrasensitive technique
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