The study is based on the genetic analysis of more than 17,000 patients and healthy control persons. As one of the largest genetic studies on Parkinson’s disease to date, for the first time the study establishes the significance of risk genes in pathogenesis, not only for the inhabitants of the western hemisphere but also for the population in the Asia-Pacific region (Neurology 11.07.2012).
Due to the rapid technical progress in genetic analyses large patient groups can be examined for risk genes for Parkinson’s disease with relatively little time expenditure. In the process, Parkinson’s patients are typically examined from specific regions, for example Western Europe or the USA, with the result that, to date, is was unclear whether and to what extent the risk factors found can be extrapolated to other population groups worldwide.
To tackle these problems, already in 2004, Tübingen physicians and researchers had founded a consortium, together with colleagues from the USA, for investigating the genetic-epidemiological causes of Parkinson’s disease (GEO-PD). The current study was funded by the Michael J Fox Foundation (MJFF) and arose as part of this consortium in collaboration with Parkinson’s specialists from 19 countries and four continents.
The DNA samples collected in this way from over 17,000 patients and control persons have now made it possible for the first time to examine the results of large genome-wide association studies in different patient populations worldwide and to define their significance for their respective population. In doing so the study reveals the particular significance of the population-specific context in interpreting and evaluating genetic risk factors.
On the basis of the study, risk genes can be named for Parkinson’s disease, which, via follow-up examinations on the affected carriers, allow predictions on the natural progression of the disease. This is a first step in the direction of future personalised risk modelling for carriers of the different gene variations.
Title of the publication: Large scale replication and heterogeneity in Parkinson desease genetic loci
Published in: Neurology „ahead of print“, 11.07.2012. Neurologydoi:
Contacts:Dr. Manu Sharma
Kirstin Ahrens | idw
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences