Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New insights contradict promising Alzheimer's research

24.05.2013
Approximately a year ago, the leading journal Science published an article about bexarotene as a potential Alzheimer’s drug.

A significant breakthrough and an important starting point for further Alzheimer’s research. The research group of Bart De Strooper – Alzheimer’s researcher at VIB and KU Leuven – in collaboration with the group of Rudi D’Hooge – KU Leuven – and scientists at Janssen Pharmaceutica, Beerse, also tested this candidate drug in various Alzheimer’s animal test models. Their results were different, as were those of two American study groups. Therefore, they have recommended in a “technical comment” in Science that bexarotene should not be tested on patients.

Bart De Strooper (Department Director VIB/KU Leuven): “Science is a learning process and one learns by trial and error and by starting again and correcting mistakes. Therefore, it is logical that conclusions from scientific research – even in prestigious journals – need to be re-evaluated from time to time. If results cannot be reproduced, it is very important that this is mentioned so that other scientists can also determine the value of a publication (reproducible science is the only true science). This is the only way that we can learn from our mistakes and hopefully one day develop a drug.”

Jo Bury (Managing Director VIB): “VIB places great value on thorough checks and balances of scientific results. This is the most important condition for leading research that could benefit our society. It is good news that Science is also prepared to publish negative results.”

Scientific research, a process of ups and downs
Scientific findings do not simply fall into someone’s lap; they are the result of years of dogged research. The icing on the cake is a publication in a scientific journal, as this is the way that scientists announce their results to the world. Before a publication is accepted, a journal will submit the document to a panel of leading scientists in that field of research. The publication is only given the go-ahead following a positive evaluation by these experts.
Built-in control mechanisms
Is this an absolute guarantee? Unfortunately not.
Fellow scientists try to reproduce results. They are usually successful, but sometimes similar experiments lead to different results. And this needs to be reported and examined in more detail. These built-in control mechanisms in the scientific process are therefore very important. It is a normal part of the scientific process. Scientific journals also sometimes offer scientists the opportunity to comment on certain publications after they have been published. The journal Science does this in the form of “technical comments”. This is often the source of more extensive research.
New insights sometimes invalidate existing theories
Scientists want to get to the bottom of phenomena, usually with a certain hypothesis in mind. Research leads to new knowledge and insights, which results in refinement of the existing theories. However, sometimes this results in a completely new theory and the rejection of an existing theory. The history of science is littered with examples of this: think of Copernicus who was the first to assert that the sun – and not the earth – is the centre of our solar system. The Flemish contribution to Science is an excellent example of the self-monitoring process in the scientific world.
Relevant publication
"Technical comment on ApoE-Directed Therapeutics Rapidly Clear b-Amyloid and Reverse Deficits in AD Mouse Models”, Ina Tesseur et al., Science 2013

Kris Van der Beken | EurekAlert!
Further information:
http://www.vib.be

Further reports about: Alzheimer Alzheimer’s drug Science TV VIB scientific research

More articles from Health and Medicine:

nachricht Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>