Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Infection in malaria-transmitting mosquito discovered

06.06.2014

Finding could lead to new strategies for malaria control

Researchers have found the first evidence of an intercellular bacterial infection in natural populations of two species of Anopheles mosquitoes, the major vectors of malaria in Africa. The infection, called Wolbachia, has been shown in labs to reduce the incidence of pathogen infections in mosquitoes and has the potential to be used in controlling malaria-transmitting mosquito populations.

"Wolbachia is an interesting bacterium that seems perfectly suited for mosquito control. However, there were strong doubts that it could ever be used against field Anopheles populations," said Flaminia Catteruccia, associate professor of immunology and infectious diseases at Harvard School of Public Health (HSPH) and at the University of Perugia, Italy. "We were thrilled when we identified infections in natural mosquito populations, as we knew this finding could generate novel opportunities for stopping the spread of malaria."

The study appears online June 6, 2014 in Nature Communications. Anopheles mosquitoes are the deadliest animal on the planet. They are responsible for transmitting malaria, which causes more than 600,000 deaths each year and puts half of the world's population at risk for diseases. Wolbachia infections spread rapidly through wild insect populations by inducing a reproductive phenomenon called cytoplasm incompatibility (CI), and 66% of arthropod species are infected. However, it was commonly thought that Anopheles mosquitoes were not natural hosts for Wolbachia infections, and attempts to identify infections in these mosquitoes in the field had failed.

Co-author Francesco Baldini, from University of Perugia, Italy and HSPH, in collaboration with researchers from CNRS, France, collected Anopheles mosquitoes from villages in Burkina Faso, West Africa, and analyzed their reproductive tracts. Their objective was to identify all the bacteria in the reproductive systems of both male and female mosquitoes; they were not looking directly for Wolbachia. To their surprise, they found a novel strain of the infection, which they named wAnga.

The researchers say they can now investigate whether the wAnga strain shares properties with other Wolbachia strains, which could make control strategies possible by inducing CI and reducing Plasmodium (the parasite that causes malaria) numbers in Anopheles mosquitoes in the field. "If successful, exploiting Wolbachia infections in malaria mosquitoes could reduce the burden of the disease globally," said co-author Elena Levashina, from the Max Planck Institute for Infection Biology, Berlin.

###

Other main authors of the study included Nicola Segata from the University of Trento, Italy, and Julien Pompon from CNRS, France.

This work was funded by a European Research Council FP7 ERC Starting Grant project 'Anorep' (grant ID: 260897), a Biotechnology and Biological Sciences Research Council grant (grant BB/I002898/1) and a Wellcome Trust grant (grant ID: 093553) to F.C., by the European Union FP7 grant (PCIG13-618833) and startup funding at the Centre for Integrative Biology (University of Trento) to N.S., by the EC FP7 Networks of Excellence EVIMalaR (242095) to E.A.L. and F.C., and by an ANR-11-BSV7-009-01 GIME to E.A.L. F.C. was supported by an NIH grant (grant ID: NIH 1R01AI104956-01A1). J.P. was supported by fellowships from FRM and the Fondation Des Treilles.

"Evidence of natural Wolbachia infections in field populations of Anopheles gambiae," Francesco Baldini, Nicola Segata, Julien Pompon, Perrine Marcenac, W. Robert Shaw, Roch K. Dabiré, Abdoulaye Diabaté, Elena A. Levashina, Flaminia Catteruccia, Nature Communications, DOI: 10.1038/ncomms4985, online June 6, 2014.

Harvard School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people's lives—not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at HSPH teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's oldest professional training program in public health.

HSPH on Twitter: http://twitter.com/HarvardHSPH

HSPH on Facebook: http://www.facebook.com/harvardpublichealth

HSPH on You Tube: http://www.youtube.com/user/HarvardPublicHealth

HSPH home page: http://www.hsph.harvard.edu

Todd Datz | Eurek Alert!

Further reports about: Anopheles HSPH Harvard Infection infections mosquito populations reproductive

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>