Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IN-TIME shows equal benefit of home telemonitoring in ICD and CRT-D patients

19.05.2014

ICD patients and CRT-D patients benefit to an almost equivalent extent from home telemonitoring

Home telemonitoring is equally effective in ICD and CRT-D patients, a subanalysis of the IN-TIME trial has shown. The findings were presented for the first time today at the Heart Failure Congress 2014, held 17-20 May in Athens, Greece. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.

The prospective IN-TIME multicentre trial included 664 patients with chronic heart failure, class II or III New York Heart Association (NYHA) symptoms and left ventricular ejection fraction <35% who were receiving optimal medical therapy. Nearly two-thirds of patients (60%) received a cardiac resynchronisation defibrillator (CRT-D) while 40% received an implantable cardioverter defibrillator (ICD).

All of the implanted devices had a home telemonitoring capability. Patients were randomised in a 1:1 fashion to have the telemonitoring function switched on or off. For those patients who had the telemonitoring function switched on, data from their device was transmitted to a monitoring physician or clinic to enable early detection of arrhythmias or other complications. Patients with the telemonitoring switched off were followed up during visits to the clinic.

... more about:
»CRT-D »Cardiology »ICD »failure »mortality »receiving »risk »therapy

The findings of the overall study were presented at ESC Congress 2013. Briefly, the trial showed that telemonitoring reduced the proportion of patients with a worsened composite clinical score consisting of all cause mortality, overnight hospitalisation for worsened heart failure, change in NYHA class, and change in patient global self assessment from 27.2% to 18.9% (p=0.013) (primary outcome). Telemonitoring also reduced one-year mortality from 8.7% to 3.4% (p=0.004) (secondary outcome).

The current subanalysis of the IN-TIME trial, presented for the first time today, investigated whether home telemonitoring was equally effective in patients with a CRT-D and patients with an ICD.

Professor Gerhard Hindricks, principal investigator of the study, said: "We predefined this subanalysis because we wanted to know if our overall findings were the same in both device types. This would have an impact on the interpretation of the data and recommendations for treatment in these patient populations."

He continued: "The patient population receiving a CRT-D is quite different to the patient population receiving an ICD. Usually the patients with an indication for CRT implantation are at higher risk of worsening of heart failure during the natural course of the disease, and they profit more from defibrillator therapy with a cardiac resynchronisation function."

The researchers found that the relative risk of the primary outcome in the telemonitoring versus control group was similar in the ICD (0.61, p=0.06) and CRT-D (0.75, p=0.10) patients. The relative risk of the secondary outcome was also similar in both device groups (ICD: 0.38, p=0.15; CRT-D: 0.35, p=0.014).

Professor Hindricks said: "This subanalysis adds to the general finding of the IN-TIME trial. We now know that ICD patients and CRT-D patients benefit to an almost equivalent extent from home telemonitoring."

He concluded: "The take home message for clinicians is that if you have a patient with advanced heart failure and an ejection fraction less than 35% who is on optimal medical therapy, consider implantation of an ICD or CRT-D that is capable of home telemonitoring. Patients on both types of devices will benefit equally from home telemonitoring, with improved clinical outcomes including reduced mortality."

Jacqueline Partarrieu | Eurek Alert!
Further information:
http://www.escardio.org

Further reports about: CRT-D Cardiology ICD failure mortality receiving risk therapy

More articles from Health and Medicine:

nachricht Newly discovered 'multicomponent' virus can infect animals
26.08.2016 | US Army Medical Research Institute of Infectious Diseases

nachricht Symmetry crucial for building key biomaterial collagen in the lab
26.08.2016 | University of Wisconsin-Madison

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Virtual Reality: 3D Human Body Reconstruction from Fraunhofer HHI digitizes Human Beings

Scientists at the Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute, HHI have developed a method by which the realistic image of a person can be transmitted into a virtual world. The 3D Human Body Reconstruction Technology captures real persons with multiple cameras at the same time and creates naturally moving dynamic 3D models. At this year’s trade fairs IFA in Berlin (Hall 11.1, Booth 3) and IBC in Amsterdam (Hall 8, Booth B80) Fraunhofer HHI will show this new technology.

Fraunhofer HHI researchers have developed a camera system that films people with a perfect three-dimensional impression. The core of this system is a stereo...

Im Focus: Streamlining accelerated computing for industry

PyFR code combines high accuracy with flexibility to resolve unsteady turbulence problems

Scientists and engineers striving to create the next machine-age marvel--whether it be a more aerodynamic rocket, a faster race car, or a higher-efficiency jet...

Im Focus: X-ray optics on a chip

Waveguides are widely used for filtering, confining, guiding, coupling or splitting beams of visible light. However, creating waveguides that could do the same for X-rays has posed tremendous challenges in fabrication, so they are still only in an early stage of development.

In the latest issue of Acta Crystallographica Section A: Foundations and Advances , Sarah Hoffmann-Urlaub and Tim Salditt report the fabrication and testing of...

Im Focus: Piggyback battery for microchips: TU Graz researchers develop new battery concept

Electrochemists at TU Graz have managed to use monocrystalline semiconductor silicon as an active storage electrode in lithium batteries. This enables an integrated power supply to be made for microchips with a rechargeable battery.

Small electrical gadgets, such as mobile phones, tablets or notebooks, are indispensable accompaniments of everyday life. Integrated circuits in the interiors...

Im Focus: UCI physicists confirm possible discovery of fifth force of nature

Light particle could be key to understanding dark matter in universe

Recent findings indicating the possible discovery of a previously unknown subatomic particle may be evidence of a fifth fundamental force of nature, according...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The energy transition is not possible without Geotechnics

25.08.2016 | Event News

New Ideas for the Shipping Industry

24.08.2016 | Event News

A week of excellence: 22 of the world’s best computer scientists and mathematicians in Heidelberg

12.08.2016 | Event News

 
Latest News

Cancer: Molecularly shutting down cancer cachexia

31.08.2016 | Life Sciences

Robust fuel cell heating unit developed

31.08.2016 | Power and Electrical Engineering

Algorithms Offer Insight into Cellular Development

31.08.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>