Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

IMRT improves outcomes in patients with extranodal lymphoma of the head and neck

15.08.2011
Lymphoma is a cancer that affects organs of the immune system, including the lymph nodes.

In a subtype of the disease called extranodal lymphoma, tumors arise in non-lymphoid organs, such as the tongue and tonsils. Patients with extranodal lymphoma of the head and neck often undergo radiation therapy, but this treatment frequently damages the salivary glands and causes dry mouth, which can lead to problems with eating, speaking and swallowing.

An advanced radiation therapy technique called Intensity Modulated Radiation Therapy (IMRT) produces no major side effects and a high response rate in patients with extranodal lymphoma of the head and neck, according to new research from Fox Chase Cancer Center. Aruna Turaka, M.D., a radiation oncologist at Fox Chase, presented the findings at the 2011 Pan Pacific Lymphoma Conference on Monday, August 15.

IMRT involves using a computer to deliver radiation doses with the optimal intensity and pattern so that the radiation beam conforms to the three-dimensional shape of the tumor and spares healthy surrounding tissue. The procedure is commonly used to treat head and neck cancer because it provides better local control rates and causes fewer side effects, such as dry mouth com pared with standard conventional radiation therapy techniques. But whether IMRT is the best radiation therapy for patients with extranodal lymphoma of the head and neck had not been previously investigated.

"IMRT is a promising technique that should be used to treat extranodal lymphoma, in addition to chemotherapy," Turaka says. "Radiation acts as a form of local treatment that prevents loco- regional relapses, and chemotherapy helps to prevent systemic relapses."

In the new study, Turaka and her colleagues identified five patients with extranodal lymphoma of the head and neck who were treated with IMRT at Fox Chase between 2007 and 2010. Four of these individuals also received chemotherapy. All of the patients had stage IEA disease, indicating that the cancer was located in a single region and there were no systemic symptoms, such as fever, drenching night sweats, and weight loss.

After treatment, the majority of patients showed improved outcomes and only minor symptoms. There were no occurrences of severe dry mouth, no relapses in the head or neck, and no evidence of tissue abnormalities appearing on positron emission tomography scans (PET) of these regions. Only one individual experienced a systemic relapse, and four people survived during the follow-up period. The findings show that IMRT helps to control local tumors while keeping side effects at a minimum.

In follow-up studies, Turaka will examine the effectiveness and side effects of IMRT, in comparison with conventional radiation therapy approaches, in a larger group of patients with extranodal lymphoma affecting various sites in the body.

"Though these types of lymphomas are rare, it's important to treat them using advanced techniques, such as IMRT, to achieve better results and give good symptom relief to patients," Turaka says.

Co-investigators include Tianyu Li, Adam D. Cohen, Nicos Nicolaou, Barbara Pro, Michael M. Millenson, Valentine Robu, Tahseen I. Al-Saleem, and Mitchell R. Smith from Fox Chase.

Fox Chase Cancer Center is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation's first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center's nursing program has received the Magnet status for excellence three consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. For more information, visit Fox Chase's Web site at www.foxchase.org or call 1-888-FOX CHASE or (1-888-369-2427).

Diana Quattrone | EurekAlert!
Further information:
http://www.foxchase.org

Further reports about: IMRT Radiation dry mouth lymphoma radiation therapy

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Satellite-based Laser Measurement Technology against Climate Change

17.01.2017 | Machine Engineering

Studying fundamental particles in materials

17.01.2017 | Physics and Astronomy

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>