Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Improved Blood Circulation in Coronary Heart Disease

18.08.2009
Researchers from Bochum and Graz investigated the mechanism of nitric oxide release

New findings about nitrovasodilators

Chest pain is the major symptom of patients with coronary heart disease. Agents that release nitric oxide (NO) within the body can help to treat such angina pectoris attacks because NO dilates arteries thereby improving blood circulation. To date, NO release from nitrovasodilators like glyceryltrinitrate is not fully understood. Pharmacologists in Bochum and Graz gained new insights into this process by analyzing the enzyme responsible for NO release. The results of this study have been published in the Journal of Biological Chemistry.

The reaction causing bioactivation is not well understood

So-called nitrovasodilators such as nitroglycerin have been used effectively in the treatment of angina pectoris in coronary heart disease for more than century. Within the human body, nitric oxide (NO) is released from the nitroglycerin and in turn stimulates an enzyme that dilates the arteries and thus improves blood circulation. In 1998, Robert F. Furchgott, Ferid Murad and Louis Ignarro were awarded the Nobel Prize for Medicine for their discoveries that nitric oxide is not only released from drugs but is being produced endogenously in the body and has an important function as a signalling molecule in the cardiovascular system.

The molecular mechanism of NO release

The positive effect of nitrovasodilators entirely depends on the release of NO or chemically related molecules within the vascular smooth muscle cells, the so called bioactivation. In 2002, Stamler and coworkers were able to identify mitochondrial aldehyde dehydrogenase-2 (ALDH2) as the enzyme responsible for bioactivation of nitroglycerin. ALDH2 is also involved in the decomposition of toxic metabolites of alcohol. Researchers from Bochum and Graz investigated the ALDH2-catalyzed bioactivation of nitroglycerin by exchanging amino acids to identify residues essential for NO release, thereby gaining insight into the catalyzed reaction. Dr. Michael Russwurm pointed out that a better understanding of bioactivation of nitrovasodilators at the molecular level is not only important for the therapeutic use of known NO donors, but also for the possible development of new NO-releasing agents. E.g. an altered bioactivation could reduce the well-known phenomenon of tolerance, i.e. the loss in efficacy of nitrovasodilators.

Title

M. Verena Wenzl, Matteo Beretta, Antonius C. F. Gorren, Andreas Zeller, Pravas K. Baral, Karl Gruber, Michael Russwurm, Doris Koesling, Kurt Schmidt and Bernd Mayer: Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2, The Journal of Biological Chemistry, Vol. 284, Issue 30, 19878-19886, JULY 24, 2009, doi:10.1074/jbc.M109.005652

Further Information

Prof. Doris Koesling, Dr. Michael Russwurm, Department of Pharmacology and Toxicology, Medical Faculty of the Ruhr-University, 44780 Bochum, Germany, Tel. 0234/32-26827, -28397, E-Mail: Doris.Koesling@rub.de, Michael.Russwurm@rub.de

Editor: Meike Drießen

Dr. Josef König, | idw
Further information:
http://www.ruhr-uni-bochum.de/

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>