Antibiotic-resistant organisms such as MRSA can cause infections after surgery. Many studies have shown that MRSA nasal colonization increases the risk of developing SSI, and there has been an effort to conduct swab testing to isolate those patients and decontaminate or reduce the risk of MRSA SSI.
Researchers led by Harry T. Papaconstantinou, MD, chief of colorectal surgery at Scott and White Memorial Hospital, sought to determine the type of infection that might occur post-gastrointestinal (GI) surgery in someone who receives a nasal swab that tests positive for MRSA. The majority of organisms that cause SSIs after GI surgery usually occur within the body cavity operated on, but MRSA tends to colonize on the skin. Therefore, researchers expected to find that nasal colonization of MRSA wouldn't have an effect, as it is not an organism that is routinely found or colonized in the GI tract.
Of the 1,137 patients identified, 6 percent were MRSA positive, 15 percent were MSSA positive and 79 percent were negative. One hundred and one patients experienced SSI (9 percent), with the MRSA-positive group associated with a higher rate of SSI when compared to the negative and methicillin-sensitive Staphylococcus aureus (MSSA)-positive groups (14 percent versus 9 percent versus 4 percent, respectively).
Researchers also looked at other potential risk factors and found that the nasal swab result was not an indication of developing an SSI. "I don't think MRSA colonization necessarily increases risk for developing SSI, but I do think that MRSA colonization affects what type of organism is involved in SSI," said Dr. Papaconstantinou. He added that if you examine the organism present in SSIs, of the patients who tested positive for MRSA, 70 percent of their wound infections stemmed from MRSA.
Dr. Papaconstantinou said it is instructive to look at this research and consider what it takes to do a nasal swab test, to identify those with Staph aureus and differentiate between MRSA and MSSA, and then look at what it would cost to decolonize those patients. The next step for this research is to conduct surveillance and eradication of MRSA in bowel surgery.
Investigators examined all patients who had nasal swab tests at Scott and White Memorial Hospital between December 2007 and August 2009, and who had also undergone major gastrointestinal surgery (surgery of the esophagus, stomach, small bowel, colon and rectum, liver, gallbladder, pancreas, etc.) Patients had a nasal swab test to determine their MRSA colonization status within 24 to 48 hours after admission and were grouped into one of three categories: MRSA swab-positive, MSSA swab-positive, or those who had neither and were considered negative.
No pharmaceutical funding was provided for this study.
Dr. Papaconstantinou will present these data on Sunday, May 20 at 10:30 a.m. PT in Room 28ab at the San Diego Convention Center.
Amy Levey | EurekAlert!
TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute
Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences