Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immunotherapy alleviates hay fever and asthma in children

20.01.2009
RUB researchers tested grass pollen tablet
Study in the Journal of Allergy and Clinical Immunology

Taking one grass pollen tablet every day can alleviate hay fever and asthma in children. These are the results of a study by medical experts in the team led by Prof. Dr. Albrecht Bufe (Experimental Pneumology) at the Ruhr-Universität Bochum.

The study was carried out jointly with national colleagues and featured 253 children. Under this particular treatment, asthma symptoms declined by 64% and hay fever symptoms by 24%. The results are published in the current issue of the Journal of Allergy and Clinical Immunology.

Dreaded allergic march

Up to 25% of the population in western industrial countries have hay fever. Far worse than the impact of the hay fever syndrome on the quality of life and capacity to work is the risk of the so-called allergic march, particularly in children: 10 to 50% of all child patients with untreated hay fever will develop asthma later on. To prevent this, medical experts opt for immunotherapies that aim to get the immune system slowly accustomed to whichever types of pollen are causing the allergy so that it no longer overreacts.

Active substance vs. placebo

This is also the aim of the grass pollen tablets which patients place once a day under their tongue where it dissolves. The participants in the study aged between 5 and 16 years were allocated at random to one of the two study groups, receiving either real tablets with active substance or placebos without active substance. Daily intake began two to six months before the start of the pollination season and continued until the season finished. The test persons kept records about their symptoms and their intake of corresponding medication, such as nasal spray or asthma spray. In addition, regular blood tests were carried out to see how their immune system reacted.

Clear improvement thanks to the grass pollen tablet.

The results confirmed the effect of the grass pollen tablets: hay fever symptoms were up 24% less pronounced in the group taking the active substance than in the placebo group. Accordingly, the group needed 34% less medication. Asthma symptoms decreased by up to 64%. The immunological blood tests confirmed the effect of the tablet. In general, the grass pollen tablets were well tolerated, apart from frequent itchiness in the mouth as a temporary side effect. "Just as with adults, this immunotherapy with the tablet being placed under the tongue is also very promising in children", concludes Prof. Bufe. Further studies will be necessary to see whether there are any long-term improvements in the allergy.

"For a long time now, standard hay fever treatment has consisted of desensitization/immunotherapy with the allergens being injected under the skin. If it transpires that the grass tablets have a similarly effective long-term impact, in future it will be possible to replace the injection therapy with sublingual treatment, and now also in children."

Prof. Dr. Albrecht Bufe | alfa
Further information:
http://www.ruhr-uni-bochum.de

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>