Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Immunotherapy alleviates hay fever and asthma in children

RUB researchers tested grass pollen tablet
Study in the Journal of Allergy and Clinical Immunology

Taking one grass pollen tablet every day can alleviate hay fever and asthma in children. These are the results of a study by medical experts in the team led by Prof. Dr. Albrecht Bufe (Experimental Pneumology) at the Ruhr-Universität Bochum.

The study was carried out jointly with national colleagues and featured 253 children. Under this particular treatment, asthma symptoms declined by 64% and hay fever symptoms by 24%. The results are published in the current issue of the Journal of Allergy and Clinical Immunology.

Dreaded allergic march

Up to 25% of the population in western industrial countries have hay fever. Far worse than the impact of the hay fever syndrome on the quality of life and capacity to work is the risk of the so-called allergic march, particularly in children: 10 to 50% of all child patients with untreated hay fever will develop asthma later on. To prevent this, medical experts opt for immunotherapies that aim to get the immune system slowly accustomed to whichever types of pollen are causing the allergy so that it no longer overreacts.

Active substance vs. placebo

This is also the aim of the grass pollen tablets which patients place once a day under their tongue where it dissolves. The participants in the study aged between 5 and 16 years were allocated at random to one of the two study groups, receiving either real tablets with active substance or placebos without active substance. Daily intake began two to six months before the start of the pollination season and continued until the season finished. The test persons kept records about their symptoms and their intake of corresponding medication, such as nasal spray or asthma spray. In addition, regular blood tests were carried out to see how their immune system reacted.

Clear improvement thanks to the grass pollen tablet.

The results confirmed the effect of the grass pollen tablets: hay fever symptoms were up 24% less pronounced in the group taking the active substance than in the placebo group. Accordingly, the group needed 34% less medication. Asthma symptoms decreased by up to 64%. The immunological blood tests confirmed the effect of the tablet. In general, the grass pollen tablets were well tolerated, apart from frequent itchiness in the mouth as a temporary side effect. "Just as with adults, this immunotherapy with the tablet being placed under the tongue is also very promising in children", concludes Prof. Bufe. Further studies will be necessary to see whether there are any long-term improvements in the allergy.

"For a long time now, standard hay fever treatment has consisted of desensitization/immunotherapy with the allergens being injected under the skin. If it transpires that the grass tablets have a similarly effective long-term impact, in future it will be possible to replace the injection therapy with sublingual treatment, and now also in children."

Prof. Dr. Albrecht Bufe | alfa
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>