Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immunotherapy alleviates hay fever and asthma in children

20.01.2009
RUB researchers tested grass pollen tablet
Study in the Journal of Allergy and Clinical Immunology

Taking one grass pollen tablet every day can alleviate hay fever and asthma in children. These are the results of a study by medical experts in the team led by Prof. Dr. Albrecht Bufe (Experimental Pneumology) at the Ruhr-Universität Bochum.

The study was carried out jointly with national colleagues and featured 253 children. Under this particular treatment, asthma symptoms declined by 64% and hay fever symptoms by 24%. The results are published in the current issue of the Journal of Allergy and Clinical Immunology.

Dreaded allergic march

Up to 25% of the population in western industrial countries have hay fever. Far worse than the impact of the hay fever syndrome on the quality of life and capacity to work is the risk of the so-called allergic march, particularly in children: 10 to 50% of all child patients with untreated hay fever will develop asthma later on. To prevent this, medical experts opt for immunotherapies that aim to get the immune system slowly accustomed to whichever types of pollen are causing the allergy so that it no longer overreacts.

Active substance vs. placebo

This is also the aim of the grass pollen tablets which patients place once a day under their tongue where it dissolves. The participants in the study aged between 5 and 16 years were allocated at random to one of the two study groups, receiving either real tablets with active substance or placebos without active substance. Daily intake began two to six months before the start of the pollination season and continued until the season finished. The test persons kept records about their symptoms and their intake of corresponding medication, such as nasal spray or asthma spray. In addition, regular blood tests were carried out to see how their immune system reacted.

Clear improvement thanks to the grass pollen tablet.

The results confirmed the effect of the grass pollen tablets: hay fever symptoms were up 24% less pronounced in the group taking the active substance than in the placebo group. Accordingly, the group needed 34% less medication. Asthma symptoms decreased by up to 64%. The immunological blood tests confirmed the effect of the tablet. In general, the grass pollen tablets were well tolerated, apart from frequent itchiness in the mouth as a temporary side effect. "Just as with adults, this immunotherapy with the tablet being placed under the tongue is also very promising in children", concludes Prof. Bufe. Further studies will be necessary to see whether there are any long-term improvements in the allergy.

"For a long time now, standard hay fever treatment has consisted of desensitization/immunotherapy with the allergens being injected under the skin. If it transpires that the grass tablets have a similarly effective long-term impact, in future it will be possible to replace the injection therapy with sublingual treatment, and now also in children."

Prof. Dr. Albrecht Bufe | alfa
Further information:
http://www.ruhr-uni-bochum.de

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>