Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immunization not linked to increased hospitalization for children with inherited disorder

11.04.2011
Study focused on ER visits or hospitalizations in children with inborn errors of metabolism

Children with inborn errors of metabolism received vaccines on the same immunization schedule as did healthy infants, according to Kaiser Permanente Vaccine Study Center scientists who examined the Kaiser Permanente Northern California population.

In addition, immunization was not associated with significant increases in emergency room visits or hospitalizations during the month following vaccination, according to Nicola Klein, MD, PhD, lead author of the study and co-director of the Kaiser Permanente Vaccine Study Center.

The study appears in the current online issue of Pediatrics.

The paper is among the first to study immunization rates and vaccine safety in children with inherited metabolic disorders, which is a potential high-risk population for vaccine-preventable illnesses. Inborn errors of metabolism comprise a large class of genetic diseases characterized by defects in enzymes required for breaking down organic compounds, said the researchers. Although each condition is individually rare, it is estimated that the collective birth prevalence is between 1 in 2,500 to 5,000 live births, they explained.

Studying infants with inborn metabolism errors compared with matched healthy controls, similar proportions of children in the Kaiser Permanente Northern California population were up to date for vaccines at 2 years of age, and there was no evidence of delay in receipt of recommended vaccines during the first year, said Klein. Importantly, vaccination of children with inborn errors of metabolism was not associated with significant increases in emergency room visits or hospitalizations during the 30 days after vaccination.

"It's important to note that children with inherited metabolic disorders are particularly vulnerable to metabolic stress, including fever that results from infections and inflammatory processes, as well as vaccine-preventable diseases," Klein said. "This study adds important information to the evidence base because it's among the largest and thus perhaps gives us the best look at this to date. The results suggest that routine vaccination of children with inborn errors of metabolism is safe, but we recognize that larger studies are needed because these conditions are so rare."

Researchers grouped inborn errors of metabolism into three groups – sickest, chronic and stable. They identified children up to 18 years old who were assigned an inborn error of metabolism diagnosis from 1990 to 2007. Researchers assessed immunization rates by comparing infants with inborn metabolism errors with matched healthy controls. Researchers then assessed for vaccine-related adverse events, defined as an emergency room visit or hospitalization, by comparing days 0-30 post vaccination versus 31-70 days post vaccination among all children with inborn errors of metabolism who were vaccinated. This was done to allow for evaluation of adverse events that could be due to both inactive and live viral vaccines. They also examined the vaccination period from 0 to 14 days post vaccination as secondary analyses.

Unlike a prior single report describing seven children with inborn errors of metabolism who experienced metabolic de-compensation after vaccination, this larger study of 271 vaccinated children with inborn errors of metabolism did not detect such an association for most children in the 30 days following vaccination, including children with inborn errors of metabolism less than 1 year old, added Klein.

Klein explained that secondary analyses indicated there may be increased rates of hospitalizations two weeks after vaccination for the sickest 1-4 year olds. This suggests that there may be a subset of more fragile children with inborn errors of metabolism at increased risk for adverse events during the immediate post vaccination period, she said.

"However, this finding should be interpreted cautiously in light of the sparse data with a small number of hospitalizations (11 during post vaccine days 0-14), the lack of a clear association with any particular vaccine(s), the long time period of which these hospital events occurred (17 years), and the lack of a corresponding increase in ER visits during the post vaccine days of 0-14."

The study also observed some evidence of increased ER visits during the two weeks after vaccination for "stable" children aged 0-18 years. Again, there were few numbers of events (13 during the post vaccine days of 0-14) which occurred over a long period of time. The lack of a corresponding increase in hospitalizations for this group is reassuring because it suggests that ER events were not serious enough to result in hospitalization, said the researchers.

"Although a larger study will be needed to investigate these observations further, it is important to consider that, for this vulnerable population, the risk of an ER visit or hospitalization following infection with a vaccine-preventable disease would likely be greater than the increased frequencies observed in this study," said Klein.

Because infants with underlying inherited metabolic disorders are especially vulnerable if unprotected against vaccine-preventable diseases, the American Academy of Pediatrics (AAP) recommends routine vaccination for children with inborn errors of metabolism, she said, explaining that this study supports that recommendation.

Co-authors on the study included: Laurie Aukes, RN, Janelle, Lee, DrPH, Bruce Fireman, MS, and Roger Baxter, MD, all with the Kaiser Permanente Vaccine Study Center; Stuart Shapira, MD, PhD, and Barbara Slade, MD, with the Centers for Disease Control and Prevention, Atlanta; and Marshall Summar, MD, with Vanderbilt University Medical Center, Nashville. The study was funded by the Clinical Immunization Safety Assessment through a subcontract with America's Health Insurance Plans under contract from the Centers for Disease Control and Prevention. Nicola Klein and Roger Baxter report research support from Merck & Co., Novartis, GlaxoSmithKline, Pfizer and Sanofi-Pasteur.

About the Kaiser Permanente Division of Research (http://www.dor.kaiser.org/)

The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and the society at large. It seeks to understand the determinants of illness and well-being and to improve the quality and cost-effectiveness of health care. Currently, DOR's 500-plus staff is working on more than 250 epidemiological and health services research projects.

About the Kaiser Permanente Vaccine Study Center

Founded in 1985, the Kaiser Permanente Vaccine Study Center began as a way of responding to numerous requests to use KP's large population for vaccine efficacy studies. Key studies have focused on Haemophilus influenza, type B (Hib), chickenpox, pneumococcus, rotavirus, and flu vaccines. The center operates 31 sites in Northern California and collaborates with KP's Northwest, Hawaii, and Colorado regions as well as participates in several Centers for Disease Control and Prevention and National Institutes of Health studies.

About Kaiser Permanente

Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve 8.7 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: www.kp.org/newscenter.

Danielle Cass | EurekAlert!
Further information:
http://www.kp.org

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>