Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immune therapy can protect against or treat later lymphoma

03.11.2009
Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital.

"Therapy with EBV-specific CTLs (cytotoxic lymphocytes) was effective for these patients who were severely immune-compromised, as the cells successfully reached the tumor, multiplied and were able to kill tumor cells" said Dr. Helen Heslop, lead author of the study and professor of pediatrics and medicine and a member of the Center for Cell and Gene therapy at BCM, The Methodist Hospital and Texas Children's. The cell remained in the body for up to nine years, providing long-term protection.

Patients who undergo the transplants are often immune-suppressed. Because most people have been infected with Epstein-Barr virus, the lack of immune protection makes their lymph system vulnerable to adverse effects of the virus, especially lymphomas that can be traced directly back to the infection.

In this study, 114 patients who had received hematopoietic or blood-related stem cell transplants from an unrelated donor or a family member whose bone marrow was not a perfect match also received infusions of immune components called T-cells that were design to target Epstein-Barr virus-infected cells. The treatment was preventive in 101 patients, none of whom developed lymphomas associated with Epstein-Barr virus infection. Eleven of 13 patients who had this disease or symptoms of it had sustained remissions.

Because the cells were marked, researchers determined that the special cells remained in the body for as long as nine years. The cost of the therapy, which spares normal cells, was estimated at just over $6,000, which compares favorably to other treatments for the disorder.

Researchers infused the cells soon after the patients received the stem cell transplants, which could account for its success, said Heslop and her colleagues.

"With such a promising therapy, it's important that it is not only effective, but that it is a cost-effective option for high-risk patients," said Heslop.

Others who took part in this research include Martin A Pule, Alexandra Rousseau, Catherine M Bollard, Malcolm K Brenner and Cliona M Rooney, all of the Center for Cell and Gene Therapy at BCM, Methodist and Texas Children's; Hao Liu and Meng-Fen Wu of the Dan L. Duncan Cancer Center at BCM, Karen S. Slobod of Novartis Vaccine & Diagnostics in Cambridge, Mass.; ,Gregory A Hale, Colton A Smith, Richard J Rochester and Julia L Hurwitz of St. Jude Children's Research Hospital in Memphis, Tenn. and Persis J Amrolia of Great Ormond St. Children's Hospital in London, UK.

Funding for this work came from the National Institutes of Health, the Leukemia and Lymphoma Society, the National Cancer Institute, the Assisi Foundation and the American Lebanese Syrian Associated Charities.

Glenna Picton | EurekAlert!
Further information:
http://www.bcm.edu
http://bloodjournal.hematologylibrary.org

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Nerves control the body’s bacterial community

26.09.2017 | Life Sciences

Four elements make 2-D optical platform

26.09.2017 | Physics and Astronomy

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>