"Therapy with EBV-specific CTLs (cytotoxic lymphocytes) was effective for these patients who were severely immune-compromised, as the cells successfully reached the tumor, multiplied and were able to kill tumor cells" said Dr. Helen Heslop, lead author of the study and professor of pediatrics and medicine and a member of the Center for Cell and Gene therapy at BCM, The Methodist Hospital and Texas Children's. The cell remained in the body for up to nine years, providing long-term protection.
Patients who undergo the transplants are often immune-suppressed. Because most people have been infected with Epstein-Barr virus, the lack of immune protection makes their lymph system vulnerable to adverse effects of the virus, especially lymphomas that can be traced directly back to the infection.
In this study, 114 patients who had received hematopoietic or blood-related stem cell transplants from an unrelated donor or a family member whose bone marrow was not a perfect match also received infusions of immune components called T-cells that were design to target Epstein-Barr virus-infected cells. The treatment was preventive in 101 patients, none of whom developed lymphomas associated with Epstein-Barr virus infection. Eleven of 13 patients who had this disease or symptoms of it had sustained remissions.
Because the cells were marked, researchers determined that the special cells remained in the body for as long as nine years. The cost of the therapy, which spares normal cells, was estimated at just over $6,000, which compares favorably to other treatments for the disorder.
Researchers infused the cells soon after the patients received the stem cell transplants, which could account for its success, said Heslop and her colleagues.
"With such a promising therapy, it's important that it is not only effective, but that it is a cost-effective option for high-risk patients," said Heslop.
Others who took part in this research include Martin A Pule, Alexandra Rousseau, Catherine M Bollard, Malcolm K Brenner and Cliona M Rooney, all of the Center for Cell and Gene Therapy at BCM, Methodist and Texas Children's; Hao Liu and Meng-Fen Wu of the Dan L. Duncan Cancer Center at BCM, Karen S. Slobod of Novartis Vaccine & Diagnostics in Cambridge, Mass.; ,Gregory A Hale, Colton A Smith, Richard J Rochester and Julia L Hurwitz of St. Jude Children's Research Hospital in Memphis, Tenn. and Persis J Amrolia of Great Ormond St. Children's Hospital in London, UK.
Funding for this work came from the National Institutes of Health, the Leukemia and Lymphoma Society, the National Cancer Institute, the Assisi Foundation and the American Lebanese Syrian Associated Charities.
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Power and Electrical Engineering
25.10.2016 | Process Engineering