Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Human vaccine against bird flu a reality with new discovery

04.03.2009
A vaccine to protect humans from a bird flu pandemic is within reach after a new discovery by researchers at the University of Melbourne, Australia

The discovery, published today in the prestigious Proceedings of the National Academy of Sciences, reveals how boosting T cell immunity could better protect humans from a bird flu pandemic.

The continued spread of the highly virulent "bird flu" virus has experts worried that we are facing a new potential influenza pandemic which could transfer between humans. Furthermore, given the bird flu is new, there is no pre-existing immunity in the population and current vaccine formulations would be useless.

"The 'Killer T cell' is the hit-man of the immune system. It is able to locate and destroy virus-infected cells in our body helping rid us of infection," said A/Prof Stephen Turner, from the Department of Microbiology and Immunology at the University of Melbourne who is a lead author on the paper.

"Unfortunately, current influenza vaccines are poor at inducing killer T cell immunity. Therefore, we wanted to see if we could improve the current vaccine formulation to induce killer T cells after vaccination," he said.

"We added a compound, known to increase immunity, to the flu vaccine in an animal model. The addition of this compound promoted significant generation of potent killer T cell immunity and provided protection from infection.

"The significance of these findings is that rather than having to design a new vaccine altogether, we can improve current flu vaccines by adding this potent immune modulator.

"With appropriate clinical testing, we could see improvements to current vaccines within the next five years."

Dr Turner said the key to vaccine effectiveness was ensuring a match between the vaccine and the current circulating flu strain. However, the spike proteins varied over the course of a flu season rendering the current vaccine ineffective. As such, the vaccine needs to be updated every year to match the likely strain for that winter.

"It is a different situation for influenza pandemics. Pandemics arise due to the introduction of a new influenza virus into human circulation. As such, there is little or no pre-existing immunity to the bird flu virus enabling it to spread rapidly."

"'Killer' T cells recognise components that are conserved between different influenza viruses. Therefore, a vaccine strategy that induced killer T cells pre-emptively would provide protection from a potential pandemic."

Rebecca Scott | EurekAlert!
Further information:
http://www.unimelb.edu.au

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>