Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Huge falls in diabetes mortality in UK and Canada since mid-1990s

Both the UK and Canada have experienced huge falls in diabetes-related mortality since the mid-1990s, with the result that the gap in mortality risk between those with and without diabetes has narrowed substantially.

The findings are in new research published in Diabetologia, the Journal of the European Association for the Study of Diabetes (EASD), and written by Dr Marcus Lind, Sahlgrenska Academy, University of Gothenburg, Sweden and colleagues.

A previous review of studied investigated diabetes mortality suggested that having diabetes increased a person’s mortality risk by 80% compared with the general population. However, many studies in the review were from before 2000, and some recent studies have suggested diabetes might increase mortality by less than this.

Thus in this new study, the authors estimated the current mortality rate ratio in patients with versus without diabetes and whether it has changed over time.

The UK and Canada were selected for analysis because the authors in both nations and Sweden are part of an ongoing collaboration, and this is a study objective that cannot be examined in many countries, since there are limited numbers of databases with long follow-up which are also population-based with mortality data on individuals both with and without diabetes. Both Canada and the UK hold such data.

The population-based databases from the province of Ontario, Canada, and The Health Improvement Network (THIN) database from the UK, from years 1996 to 2009 were used to calculate mortality rates in persons with and without diabetes.

The excess risk of mortality estimated during 2009 was 51% in Ontario and 65% in THIN for diabetic patients on a group level, compared to 90% and 114%, respectively, in the year 1996. The excess risk of mortality for diabetic patients declined to a similar extent for men and women over the study period, and no significant differences between sexes were observed in 2009.

“It is noteworthy that the prevalence of diabetes in Ontario (adults 20 years or older) increased from 5.4% to 11.4% over the study period, and in the THIN cohort there was an increase in prevalence from 3.2% to 5.9% over the corresponding time period,” says Lipscombe.

The excess risk of mortality for diabetic patients decreased in all age groups over time—approximately 25%-40% lower in age groups below 64 years and 50%-65% lower in those aged 64 years and older during the study period. In 2009 the excess risk of mortality for individuals with diabetes 20-44 years of age was 70%-80% in both cohorts. In those 45-64 years old, mortality was approximately doubled and was 15-25% greater in individuals 65 years of age and over.

The authors say that more aggressive treatment during recent decades may explain these results, including more intensive control of blood sugar in people with diabetes, and blood pressure control and statins to reduce the risk of cardiovascular events in people both with and without diabetes.

A shift towards more diabetes screening and earlier diagnosis in recent years may also have contributed to lower mortality rates within more contemporary diabetes populations.

Although not a primary focus of this study, the authors say it should be noted that the prevalence of diabetes was considerably higher in the Ontario cohort than in THIN during the study period. The reasons for this discrepancy are unclear, but may be related to differences in factors known to influence the incidence of diabetes such as screening programmes, ethnicity, eating habits or physical activity patterns between the two cohorts. Further research would be needed to explore these possibilities.

The authors conclude: “The excess risk of age-standardized mortality in patients with versus without diabetes has decreased over time in both Canada and the UK, having fallen to an increased risk of 50-65% in 2009. The excess risk related to diabetes however varies by age:70%-80% in individuals 20-44 years of age, approximately double in those aged 45-64 years, and 15%-25% greater in individuals above age 65 years and over.”

For more information please contact:
Dr Marcus Lind, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. T) +46 (0)738 31 17 42 / +46-(0)10-4350000 E) /

Dr Lorraine Lipscombe, Women’s College Hospital, Women’s College Research Institute, Toronto, ON, Canada, please contact Julie Saccone in Communications Department. T) +1 416-323-6400, ext.4054
E) /

Alternative contact: Tony Kirby at Tony Kirby PR Ltd T) +44 7834 385827 E)

Annika Koldenius | idw
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>