Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Host cholesterol secretion likely to influence gut microbiota

19.12.2012
For more than half a century, researchers have known that the bacteria that colonize the gastrointestinal tract of mammals influence their host's cholesterol metabolism.

Now, Jens Walter and colleagues of the University of Nebraska show that changes in cholesterol metabolism induced by diet can alter the gut flora. The research was published online ahead of print in the journal Applied and Environmental Microbiology.

In the study, the researchers added plant sterol esters to the diets of hamsters. The overall effect of this was to inhibit several bacterial taxa, from the families Coriobacteriacea and Erysipelotrichaceae, says Walter. But the immediate effect of the plant sterols was to physically block cholesterol absorption by the intestine. That decreased cholesterol levels in the liver and the plasma, prompting the hamster's body to respond by synthesizing more cholesterol. That, in turn, boosted cholesterol excretion into the gut, and that extra cholesterol was the direct inhibitor of those bacterial families.

"The abundance of these bacterial taxa and the levels of cholesterol in the fecal samples followed a mathematical model of bacterial inhibition," says Walter.

Practically speaking, the microbial inhabitants of the gut are part of the metabolic system. Researchers have shown that certain health problems are related to changes in the gut flora, such as can be induced by overuse of antibiotics. Since changes in diet can influence composition of the gut flora, health problems such as obesity might be targeted by dietary interventions designed to suppress bacteria that contribute to weight gain. "However, for these to be successful, we need to know which bacterial patterns not only are associated with disease, but actually contribute to it," says Walter, noting that his research showed that some alterations associated with metabolic disease might be the consequence, rather than the cause of the disorder.

Walter says that the work was a real student project. Among the coauthors, three were graduate students, and two were undergraduates. "As a supervisor, it is extremely nice to see young scientists work as a team, and staying dedicated through the five years that this project took to complete," he says.

A copy of the manuscript can be found online at http://bit.ly/asmtip1212b. Formal publication is scheduled for the January 2013 issue of Applied and Environmental Microbiology.

(I. Martinez, D.J. Perdicaro, A.W. Brown, S. Hammons, T.J. Carden, T.P. Carr, K.M. Eskridge, and J. Walter, 2012. Diet-induced alterations of host cholesterol metabolism are likely to affect gut microbiota composition in hamsters. Appl. Environ. Microbiol. 2012 Nov 2. [Epub ahead of print])

Applied and Environmental Microbiology is a publication of the American Society for Microbiology (ASM). The ASM is the largest single life science society, composed of over 39,000 scientists and health professionals. Its mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.

Jim Sliwa | EurekAlert!
Further information:
http://www.asmusa.org

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>