Tubal ectopic pregnancy (TEP) is currently the leading cause of pregnancy-related deaths during the first trimester and a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) shows that the hormone adrenomedullin (ADM) may help predict this condition.
TEP is a condition where the fertilized egg implants in the fallopian tubes instead of in the uterus. In pregnant women, cilia (small protuberances) pulsate, or beat, to propel an embryo through the fallopian tubes towards the uterus. Defects in ciliary beats and muscle contractions may predispose a woman to TEP. With rare exceptions, ectopic pregnancies are not viable, and they are also dangerous for the mother and without proper treatment, can lead to death.
"This is the first report to address the effect of ADM on cilia beat frequency and muscular contraction in the oviduct," says the lead author of this study, Wai-Sum O, PhD, of the University of Hong Kong. "We found that low ADM expression may contribute to slower muscle contraction and ciliary beating, which hampers embryo transport and favors embryo retention in the oviduct. This finding is significant because plasma ADM levels may be useful in predicting TEP."
In this study, researchers examined women who were having their fallopian tubes removed or were having a hysterectomy for non-cancerous reasons. Each participant had tissue from their oviduct incubated in conditions to replicate the hormonal state of early pregnancy. In the oviducts of patients who had TEP, the ciliary beats were slower, the muscle contractions were less frequent, and there were lower levels of ADM than in the oviducts from a normal pregnancy. Administering ADM reversed the retardation of ciliary beating and muscle contraction and restored them to normal levels.
"We reported for the first time a significantly reduced expression of ADM in human oviduct tissue in TEP compared to control," said O. "ADM increases cilia motility, smooth muscle tone and contraction frequency, and the reduced ADM level in TEP may contribute to its pathogenesis by impairing embryo transport."
Other researchers working on the study include: Liao SB, Li HWR, Ho JC, Yeung WSB, Ng EHY, Cheung ANY, and Tang F, all of The University of Hong Kong.
The article, "Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy," appears in the June 2012 issue of JCEM.
Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 15,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.
Aaron Lohr | EurekAlert!
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
19.06.2018 | Physics and Astronomy
19.06.2018 | Life Sciences
19.06.2018 | Physics and Astronomy