A clinical trial of Exsulin, an innovative new treatment that targets the underlying cause of type 1 diabetes, has begun at the McGill University Health Centre (MUHC). Under the direction of Dr. George Tsoukas of the MUHC and the McGill University Faculty of Medicine, the study will assess the effectiveness of Exsulin.
This potentially groundbreaking therapy was made possible by fundamental research led by Dr. Lawrence Rosenberg of the MUHC and McGill University Faculty of Medicine. The study is conducted in partnership with the Mayo Clinic in Rochester, Minnesota.
Type 1 diabetes is triggered when a patient’s immune system attacks and destroys insulin-producing beta cells in the pancreas. This prevents normal insulin secretion and the normal regulation of blood sugar levels. There is currently no cure for type 1 diabetes and it can only be controlled through regular insulin injections. Although these injections partially avoid sugar level fluctuations in the blood they do not prevent the onset of other complications.
Dr. Rosenberg and his colleagues have been working on an Exsulin-based treatment to stimulate the regrowth of insulin-producing beta cells in diabetic patients for more than 25 years.
“Exsulin has already been tested in animal models of diabetes,” he explained. “These experiments demonstrated that Exsulin injections help restore insulin production in animals whose insulin production had been lost. For example, mice injected with this new molecule were cured of their diabetes.”
The results of previously conducted human trials have indicated that Exsulin triggers at least a partial recovery of natural insulin secretion. Although at this stage of development it may not completely control the amount of circulating glucose, Exsulin does improve glucose homeostasis, which prevents the dramatic fluctuations that can lead to the main complications of diabetes: neuropathy, renal failure, blindness and heart disease. This new clinical trial aims to test a new formulation of Exsulin and to establish the best dosing schedule, as well as the most effective dosage.
“This means that Exsulin could help rebuild the islets’ entire structure, restoring near-normal metabolic control—something that insulin injections alone cannot do,” concluded Dr. Rosenberg.
Dr. Lawrence Rosenberg is Chief of the Division of Surgical Research, and Professor of Surgery and Medicine at McGill’s Faculty of Medicine. He holds the A.G. Thompson Chair in Surgical Research at the MUHC and is also an investigator in the Endocrinology, Diabetes, Nutrition and Kidney Diseases Axis of the Research Institute of the MUHC. Dr Rosenberg is also Chief of Surgical Services at the SMBD-Jewish General Hospital.
Dr. George Tsoukas is a senior member of the Department of Endocrinology at the MUHC and he currently supervises the Montreal General Hospital Diabetes Clinic at the MUHC. He is also a clinical investigator in the “Musculoskeletal Disorders” axis at the Research Institute of the MUHC and has been involved in many clinical trials involving diabetes and associated illnesses. Dr. Tsoukas is an Associate Professor in the Faculty of Medicine at McGill University.Funding
Julie Robert | MUHC Public Affairs
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy