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"Hidden" fragrance compound can cause contact allergy


Linalyl acetate, a fragrance chemical that is one of the main constituents of the essential oil of lavender, is not on the list of allergenic compounds pursuant to the EU Cosmetics Directive. Thus, it does not need to be declared on cosmetic products sold within the EU. Recent studies at the University of Gothenburg have shown that linalyl acetate can cause allergic eczema.

In accordance with the EU Cosmetics Directive, makeup, ointments, shampoo, deodorants, toothpaste and other products must contain a declaration of ingredients in order for consumers to avoid the substances to which they are allergic.

A person tested for contact allergy

University of Gothenburg

Cause of contact allergy
Linalyl acetate, a fragrance chemical, is an exception—it is not listed in the Directive and does not have to appear in declarations of ingredients. The substance is mildly allergenic. New studies at Sahlgrenska Academy have found that it can react with oxygen in the air to form strongly allergenic hydroperoxides. Thus, linalyl acetate may be a common cause of contact allergy.

Allergic reactions
The study included 1,717 subjects who were being assessed for eczema related to contact allergy. Approximately 2% of them had allergic reactions to oxidized linalyl acetate.

"That may seem like a small percentage," says Lina Hagvall, a researcher at the University of Gothenburg. "But it is approximately the same result as for the fragrance compounds listed in the Cosmetics Directive."

Broad range of tests
The subjects who reacted to oxidized linalyl acetate were also exposed to other fragrance compounds that are part of routine testing these days. A total of 57% of them had no allergic reaction.

"The trials suggest that a broad range of tests is required to detect contact allergies to fragrance compounds," Dr. Hagvall says. "Current tests do not identify the majority of people who have contact allergy to oxidized linalyl acetate.”

Hard to avoid
Because the substance is not declared on cosmetic products, consumers have trouble avoiding it, which can turn allergic eczema into a more severe, long-term condition.

According to the researchers, the study findings should lead to inclusion of oxidized linalyl acetate among the fragrance compounds used for diagnosis of contact allergy. The substance should also appear in the declaration of ingredients for cosmetic products.

"Air-oxidized linalyl acetate – An emerging fragrance allergen?" has been published in Contact Dermatitis.

Link to article:

Contact allergy involves development of an immunological memory for chemicals in the environment. The allergy generally manifests as eczema in the area of contact with the foreign substance. The allergic reaction arises when the substance bonds with skin proteins and triggers an immune response. Long-term contact can cause chronic, difficult-to-treat eczema.

The most frequent source of contact allergy is exposure to fragrance compounds, metals and preservatives. The Cosmetics Directive lists 26 fragrance chemicals and 2 natural extracts that must appear in declarations of ingredients.

For additional information, feel free to contact:
Lina Hagvall, PhD, Researcher, Sahlgrenska Academy, University of Gothenburg
Office +46 31-342 13 38

Weitere Informationen:

Henrik Axlid | idw - Informationsdienst Wissenschaft

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