When it comes to understanding the effectiveness and safety of using herbal therapies with other drugs, much is unknown. Now, a University of Missouri researcher will study how black cohosh - an herbal supplement often used to relieve hot flashes in menopausal women - interacts with tamoxifen, a common drug used to treat breast cancer.
To study how black cohosh and tamoxifen interact, Ruhlen will use a group of rats prone to breast cancer, known as ACI rats. Previous studies have found that human breast cancer is associated with life-time exposure of estrogen. ACI rats, like humans, develop mammary tumors after exposure to estrogen. In a previous study, Ruhlen found that when ACI rats were treated with the human breast cancer drug tamoxifen, mammary tumor mass was reduced by 89 percent.
“Many animal models of breast cancer differ in important ways from humans with breast cancer,” Ruhlen said. “These models are useful in studying how human tumors grow and spread to other parts of the body, but fall short because of the difference in how human tumors begin. However, mammary tumors in ACI rats share several key features with the majority of human breast cancers, particularly in how tumors start. Because the ACI rats develop tumors and can be treated in a way similar to humans, it is a relevant model for human breast cancer.”
Ruhlen’s research on black cohosh and tamoxifen is funded by Susan G. Komen for the Cure. Her paper, “Tamoxifen induces regression of estradiol-induced mammary cancer in ACI.COP-Ept2 rat model,” will be published in Breast Cancer Research and Treatment. Ruhlen works with Salman Hyder, a professor of biomedical sciences in the College of Veterinary Medicine and investigator in the Dalton Cardiovascular Research Center.
Kelsey Jackson | EurekAlert!
Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications
Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine