Every year, 15 to 20 people in Switzerland lose a hand in an accident. Provided suitable preconditions are met, a hand transplant is the best treatment method, particularly for patients who have lost both hands.
The main problem with this treatment is that patients have to be immunosuppressed, i.e. their total immune system has to be brought down with drugs to prevent their organism rejecting the foreign tissue. This treatment is associated with undesirable side effects and impairments to the quality of life. Until now though, patients have had no other option.
In laboratory experiments on rats, it has now been possible to replace systemic (total) immunosuppression with a local treatment of the transplanted limb. This has been successfully achieved by a research team from the Department of Plastic and Hand Surgery, Inselspital, and the Department of Clinical Research (DKF) of the University of Bern under the direction of scientist Dr Thusitha Gajanayake from Sri Lanka.
Professor Robert Rieben from the DKF, Head of Research in hand transplantation: "The results are very promising. Just a single treatment results in the complete prevention of a rejection reaction."
Professor Esther Vögelin, Senior Consultant and Co-Director of the Department of Plastic and Hand Surgery: "This laboratory success means that in future hand transplant patients can hope for a significant improvement in quality of life, because systemic immunosuppression could be reduced or omitted altogether."
The Bern research team is now working with great zeal towards its long-term goal of performing a hand transplant in Switzerland. In the longer term this should be done with an optimised approach to immunosuppression. In fact the latter would be a world's first.
On 2 September, international experts from the USA, India and Austria will discuss the new method at the invitation of the DKF research team in Bern.
Nathalie Matter | Universität Bern
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy