Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Halting immune response could save brain cells after stroke

14.03.2014

A new study in animals shows that using a compound to block the body's immune response greatly reduces disability after a stroke.

The study by scientists from the University of Wisconsin School of Medicine and Public Health also showed that particular immune cells – CD4+ T-cells produce a mediator, called interleukin (IL) -21 that can cause further damage in stroke tissue. Moreover, normal mice, ordinarily killed or disabled by an ischemic stroke, were given a shot of a compound that blocks the action of IL-21. Brain scans and brain sections showed that the treated mice suffered little or no stroke damage.

"This is very exciting because we haven't had a new drug for stroke in decades, and this suggests a target for such a drug," says lead author Dr. Zsuzsanna Fabry, professor of pathology and laboratory medicine.

Stroke is the fourth-leading killer in the world and an important cause of permanent disability. In an ischemic stroke, a clot blocks the flow of oxygen-rich blood to the brain. But Fabry explains that much of the damage to brain cells occurs after the clot is removed or dissolved by medicine. Blood rushes back into the brain tissue, bringing with it immune cells called T-cells, which flock to the source of an injury.

The study shows that after a stroke, the injured brain cells provoke the CD4+ T-cells to produce a substance, IL-21, that kills the neurons in the blood-deprived tissue of the brain. The study gave new insight how stroke induces neural injury.

Fabry's co-author Dr. Matyas Sandor, professor of pathology and laboratory medicine, says that the final part of the study looked at brain tissue from people who had died following ischemic strokes. It found that CD4+ T-cells and their protein, IL-21 are in high concentration in areas of the brain damaged by the stroke.

Sandor says the similarity suggests that the protein that blocks IL-21 could become a treatment for stroke, and would likely be administered at the same time as the current blood-clot dissolving drugs.

"We don't have proof that it will work in humans," he says, "but similar accumulation of IL-21 producing cells suggests that it might."

Graduate student Benjamin S. D. Clarkson and scientist Changying Ling were key members of the UW research team, as was Dr. Dandan Sun, formerly of the UW neurosurgery department and now at the University of Pittsburgh, and Dr. Vijay Kuchroo, of the Harvard Medical School.

The paper was published this week in the Journal of Experimental Medicine. A link is available here: http://bit.ly/NToPfg

###

The study was supported by the American Heart Association/American Stroke Association, the UW Cellular and Molecular Pathology Graduate Program and the National Institutes of Health via grant numbers NS037570, NS076946, AI048087 and AI068730.

Susan Lampert Smith | EurekAlert!

Further reports about: CD4+ Medicine brain cells clot damage immune injury interleukin ischemic stroke stroke

More articles from Health and Medicine:

nachricht Quenching the thirst for clean, safe water
30.04.2015 | Michigan State University

nachricht Pancreatic cancer risk linked to weak sunlight
30.04.2015 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Erosion, landslides and monsoon across the Himalaya

Scientists from Nepal, Switzerland and Germany was now able to show how erosion processes caused by the monsoon are mirrored in the sediment load of a river crossing the Himalaya.

In these days, it was again tragically demonstrated that the Himalayas are one of the most active geodynamic regions of the world. Landslides belong to the...

Im Focus: Through the galaxy by taxi - The Dream Chaser Space Utility Vehicle

A world-class prime systems integrator and electronic systems provider known for its rapid, innovative, and agile technology solutions, Sierra Nevada Corporation (SNC) is currently developing a new space transportation system called the Dream Chaser.

The ultimate aim is to construct a multi-mission-capable space utility vehicle, while accelerating the overall development process for this critical capability...

Im Focus: High-tech textiles – more than just clothes

Today, textiles are used for more than just clothes or bags – they are high tech materials for high-tech applications. High-tech textiles must fulfill a number of functions and meet many requirements. That is why the Fraunhofer Institute for Silicate Research ISC dedicated some major developing work to this most intriguing research area. The result can now be seen at Techtextil trade show in Frankfurt from 4 to 7 May. On display will be novel textile-integrated sensors, a unique multifunctional coating system for textiles and fibers, and textile processing of glass, carbon, and ceramics fibers to fiber preforms.

Thin materials and new kinds of sensors now make it possible to integrate silicone elastomer sensors in textiles. They are suitable for applications in medical...

Im Focus: Fast and Accurate 3-D Imaging Technique to Track Optically-Trapped Particles

KAIST researchers published an article on the development of a novel technique to precisely track the 3-D positions of optically-trapped particles having complicated geometry in high speed in the April 2015 issue of Optica.

Daejeon, Republic of Korea, April 23, 2015--Optical tweezers have been used as an invaluable tool for exerting micro-scale force on microscopic particles and...

Im Focus: NOAA, Tulane identify second possible specimen of 'pocket shark' ever found

Pocket sharks are among the world's rarest finds

A very small and rare species of shark is swimming its way through scientific literature. But don't worry, the chances of this inches-long vertebrate biting...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HHL Energy Conference on May 11/12, 2015: Students Discuss about Decentralized Energy

23.04.2015 | Event News

“Developing our cities, preserving our planet”: Nobel Laureates gather for the first time in Asia

23.04.2015 | Event News

HHL's Entrepreneurship Conference on FinTech

13.04.2015 | Event News

 
Latest News

Dust from the Sahara Desert cools the Iberian Peninsula

30.04.2015 | Earth Sciences

Desirable defects

30.04.2015 | Life Sciences

Germany's DanTysk Offshore Wind Power Plant Inaugurated

30.04.2015 | Press release

VideoLinks
B2B-VideoLinks
More VideoLinks >>>