Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth in cerebral aneurysms increases risk of rupture

02.07.2013
Cerebral aneurysms of all sizes—even small ones below seven millimeters—are 12 times more likely to rupture if they are growing in size, according to a new study published online in the journal Radiology.

A cerebral aneurysm is a balloon-like bulge in a weakened blood vessel in the brain. If an aneurysm ruptures, blood is leaked into or around the brain, which can cause brain damage or death.

According to The Brain Aneurysm Foundation, an estimated 6 million people in the United States have an unruptured brain aneurysm, or 1 in 50 people. Ruptured brain aneurysms occur in approximately 30,000 Americans each year and are fatal in about 40 percent of cases. Of those who survive, about two-thirds suffer some permanent neurological deficit.

"Given what a devastating event a ruptured brain aneurysm is, we are very motivated to identify the real risk factors for rupture," said the study's lead author, J. Pablo Villablanca, M.D., chief of diagnostic neuroradiology at the David Geffen School of Medicine at the University of California, Los Angeles.

In Dr. Villablanca's study, 258 asymptomatic cerebral aneurysms identified either incidentally or during a baseline study of 165 patients (132 women, 33 men) were monitored over time (mean of 2.24 years) with computed tomography angiography (CTA), a noninvasive imaging study of the brain's blood vessels. Patients were scanned with CTA at intervals of six or 12 months.

Over the study period, the researchers observed growth in 46 or nearly 18 percent of all the intracranial aneurysms in a total of 38 patients. Three of the 39 growing saccular aneurysms ruptured, and of those, all were less than seven millimeters in size at study entry.

"Our study shows that the size of the aneurysm is not as important as was once thought," Dr. Villablanca said. "Any aneurysm is potentially capable of growth and thus requires follow-up imaging."

Current guidelines based on research conducted by the International Study of Unruptured Intracranial Aneurysms and other studies suggest that known aneurysms less than seven millimeters in size have a low risk of rupture and do not need to be monitored with imaging.

Compared to the aneurysms that stayed the same size, the 46 growing aneurysms in the study were associated with a 12-fold higher risk of rupture. The researchers calculated the risk of rupture for growing aneurysms at 2.4 percent per patient-year, versus 0.2 percent for aneurysms without growth.

"Our data support the need to perform longitudinal follow-up imaging to monitor for possible growth in all incidental unruptured aneurysms, including small lesions," Dr. Villablanca said.

The researchers also found that tobacco smoking and the initial size of the aneurysm were independent predictors of aneurysm growth. Together, these risk factors were associated with 78.4 percent of all aneurysm growth in the study.

"The positive association between aneurysm growth, aneurysm size, and cigarette smoking suggests that the combination of these factors are associated with an increased risk of rupture and may influence the need for therapeutic intervention," Dr. Villablanca said.

Observation was the treatment of choice for 194 of 212 (91 percent) stable aneurysms. When aneurysm growth was discovered by CTA imaging, 50 percent of the growing aneurysms were treated, while the remaining 50 percent continued to be observed.

"The Natural History of Asymptomatic Unruptured Cerebral Aneurysms Evaluated at CT Angiography: Growth and Rupture Incidence and Correlation with Epidemiologic Risk Factors." Collaborating with Dr. Villablanca were Gary R. Duckwiler, M.D., Reza Jahan, M.D., Satoshi Tateshima, M.D., Ph.D., Neil A. Martin, M.D., John Frazee, M.D., Nestor R. Gonzalez, M.D., James Sayre, Ph.D., and Fernando V. Vinuela, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 51,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on CTA, visit RadiologyInfo.org.

Linda Brooks | EurekAlert!
Further information:
http://www.rsna.org

Further reports about: Aneurysm CTA Radiological Society blood vessel brain aneurysm cerebral risk factor

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>