"But we believe you have to have a lot of approaches working together, because the brain is very complex," she said.
The PNAS paper was a starting point, Lim said, and her team's next step is to "tweak" the molecule and then test its ability to interfere with plaque formation in fruit flies.
"We want to modify them for the brain, specifically to interfere with the plaques associated with Alzheimer's," she said.
Lim plans to collaborate with Bing Ye, a neurobiologist in the LSI. Together, the researchers will test the new molecule's power to inhibit potential toxicity of aggregates containing proteins and metals in fruit flies.
Other authors of the paper, all from U-M, are: Sanghyun Lee and Jung-Suk Choi of the Life Sciences Institute; Alaina DeToma, Suk-Joon Hyung, Akiko Kochi and Brandon Ruotoloa of the Department of Chemistry; and Jeffrey Brender, Ayyalusamy Ramamoorthy and Subramanian Vivekanandan of the Department of Chemistry and Biophysics.
The work was supported by the National Institutes of Health, Alzheimer's Association, Alzheimer's Art Quilt Initiative, American Heart Association, and a Graduate Research Fellowship from the National Science Foundation Study: http://www.pnas.org/content/early/2013/02/19/1220326110.abstract
Laura J. Williams | EurekAlert!
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