Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic risk factor associated with claw problems in dogs identified

26.08.2010
The immune-mediated disease SLO can lead to severe claw problems in dogs.
Researchers have now identified genetic risk factors underlying this disease.
The obtained results that were recently reported in the scientific journal PLoS ONE can lead to increased knowledge about similar nail diseases that affect humans.

Researchers at the Swedish University of Agricultural Sciences (SLU), Norwegian School of veterinary Science (NVH), and Uppsala University (UU) have identified one of the genetic risk factors responsible for development of an autoimmune disease affecting the claws. The study is an example of a well-established collaboration between geneticists and veterinarians at the three universities.

A disease called Symmetrical Lupoid Onychodystrophy (SLO), which is an immune-mediated disease with suspected autoimmune etiology, causes the claw problems that were analyzed. This means that the body’s own immune system reacts abnormally which leads to sloughing of claws from claw beds.

As the disease progresses all claws will become affected and this ultimately leads to destruction of the underlying claw tissue and deformation of the claws. The disease is painful and involves large degree of pain and suffering for affected dogs.

– SLO is a disease that affects many different dog breeds and in this study the researchers have focused on a few breeds with high incidence of the disease; Gordon Setter, Bearded Collie and Giant Schnauzer, says PhD student Maria Wilbe who is the first author of the report.

The identified genetic risk factors are genes in the major histocompatibility complex (MHC) class II region that encodes proteins that control the immune response. These genes have been shown to be important genetic risk factors for different autoimmune diseases in both dogs and humans.

When the immune system is activated, MHC proteins determine towards which molecules the attack should be directed. In autoimmunity, MHC proteins will erroneously recognize the body’s self-molecules and trigger destruction of the body’s own tissues and organs. Such disturbances can, in certain cases, result in development of autoimmune diseases like for example SLO.

– We have earlier shown that MHC class II is a genetic risk factor for some other autoimmune diseases in dogs, says Maria Wilbe. In the current study, we identify both a protective MHC class II type and another one that leads to increased risk for the claw disorder.

A major increased risk for SLO development was found in Gordon Setter dogs that had inherited the MHC class II risk type from both parents. In dogs that had inherited the two variants from either parents it was found that the effect of the protective type dominated and such dogs were healthy.

– The molecules in claw tissue that the affected dogs react against remain unknown, states Frode Lingaas, NVH, and Göran Andersson, SLU, who jointly have directed the genetic analyses.

The researchers are currently pursuing additional genetic research and are hopeful to fund continuous research to identify additional genetic risk factors for this claw disease.

– The finding that dogs with two copies of the MHC type that leads to increased risk, as well as the finding that the effect of the protective MHC class II type dominates, are two important findings that have increased our knowledge about how this claw disease develops. The research is yet another good example for how genetic studies, using the dog as a model for complex diseases, lead to increased knowledge.

Maria Wilbe, PhD student Department of Animal Breeding, SLU + 46 184714973,
+ 46 736-551989 maria.wilbe@hgen.slu.se
Frode Lingaas, professor, Norwegian School of Veterinary Science Frode.Lingaas@nvh.no

Göran Andersson, professor, Department of Animal Breeding, SLU + 46 18-4714903, + 46 703-808919 goran.andersson@hgen.slu.se

Pressofficer Carin Wrange; +46-70 247 84 22, Carin.Wrange@adm.slu.se

Carin Wrange | idw
Further information:
http://www.vr.se
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012332

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical Nanoscope Allows Imaging of Quantum Dots

Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.

Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Rutgers scientists discover 'Legos of life'

23.01.2018 | Life Sciences

Seabed mining could destroy ecosystems

23.01.2018 | Earth Sciences

Transportable laser

23.01.2018 | Physics and Astronomy

VideoLinks Science & Research
Overview of more VideoLinks >>>