A next generation genome sequencer has been received in the newly launched Center for Translational Oncology Mainz and Immunology (TrOn) in Mainz. With the Illumina HiSeq 2000 instrument, the genetic material of cells can be completely decoded within a few days.
"The performance of TrOn as an innovation center and hub of the CI3 regional network of science and business is strengthened by this technology. This is therefore another important step to make Mainz a globally competitive center for personalized medicine," says Univ.-Prof. Dr. Ugur Sahin, director of TrOn. “The new technology allows us to examine the genetic information in tumor and immune cells quickly and inexpensively in order to gain a better understanding of the interplay of cancer treatment and immune system. This is necessary to develop customized therapies for individual patients."
"The new instrument is eight times more powerful than previous methods," says Dr. John Castle, head of Bioinformatics/Genomics at TrOn. "This represents not only a significant reduction of time and costs, but also more information that must be analyzed. For this, we are well positioned by our cooperation with the University of Mainz Center for High Performance Computing (ZDV)."
Understanding the characteristics of individual cancer patients is the basis for a customized treatment and thus critical to a successful therapy. "Individualized" and targeted medicine offers a great promise to significantly improve cancer therapy, both decreasing the cost of health care and improving patient lives. The dramatically increased ability to decode genomes ushered in by this next era of DNA sequencing makes the vision possible.
University President Univ.-Prof. Dr. Georg Krausch, a member of the successful Mainz "City of Science 2011" team, commented: "This is one of the puzzle pieces which we want at our site: cutting-edge research to resolve major social challenges."Press contact
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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