"Obesity significantly increases the risk for diabetes, cardiovascular disease, stroke and some cancers," says Dr. Matthew During, senior author and professor in Ohio State Medical Center's department of molecular virology, immunology and medical genetics.
"Our findings represent a promising new treatment for obesity that could ultimately provide a much safer and more effective approach than some conventional therapies."
Scientists have discovered that a particular gene, BDNF, can result in improved insulin sensitivity, reduced fat mass and weight loss when active in the hypothalamus. The findings are published online in the journal Nature Medicine.
According to first author Lei Cao, assistant professor in the department of molecular virology, immunology and medical genetics, the study involved injecting the BDNF gene in normal mice, diabetic mice and mice fed with a high fat diet, to determine how the gene transfer would affect their weight. "The gene was active in the overweight mice, but as they lost weight the gene expression was essentially 'dialed down,' using a novel RNA interference approach, thus stopping the weight from continuing to decrease and allowing a stable target weight to be reached," she says.
During indicated that with the initial results showing great promise, the next step is to obtain the necessary FDA approvals to begin studying the therapy in humans at OSU Medical Center and other centers around the country.
According to the Centers for Disease Control and Prevention, more than one-third of U.S. adults, or 72 million people, and 16 percent of U.S. children are obese. Since 1980, obesity rates for adults have doubled and rates for children have tripled.
Approximately 24 million U.S. children and adults, nearly eight percent of the population, have diabetes, according to the American Diabetes Association. An estimated 18 million people have been diagnosed with the disease, but nearly six million people are unaware that they have diabetes.
Doug Flowers | EurekAlert!
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences