Approximately half of the world's population are infected with Helicobacter pylori, found primarily in the stomach. The majority never show any symptoms, but just over ten per cent develop gastric ulcers, while around one per cent develop gastric adenocarcinoma. Without antibiotics the body is unable to rid itself of the bacteria.
"Helicobacter pylori inhibits our immune defence, preventing it from attacking the bacteria with sufficient strength, despite an immune response being activated," says biologist Malin Hansson, the author of the thesis.
When an immune response is initiated a specific type of cell migrates to the lymph nodes to activate new immune cells, telling them where they need to go to tackle the infection. Infection with Helicobacter pylori prevents many of these cells from reaching their intended destination.
"Helicobacter pylori causes immune cells to accumulate in tissue. Many of the cells that ought to collect more new immune cells stop at these accumulations and begin activating these instead, leading to chronic inflammation, which we believe benefits Helicobacter pylori," says Malin Hansson.
This thesis also paves the way for a future vaccine against gastric adenocarcinoma. Previous research has shown that many infected patients with gastric adenocarcinoma have low levels of a specific type of antibody in tissue, even though Helicobacter pylori normally causes unusually high levels of antibodies. These antibodies should therefore be able to protect against this form of cancer. For the first time in samples taken from humans Malin Hansson has been able to show that these antibodies are attracted to tissue by a signal substance called MEC.
"If these antibodies really can protect against development of gastric adenocarcinoma, it would be possible to develop a vaccine that increases MEC expression and thus the number of antibodies present in tissue," says Malin.
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News