Approximately half of the world's population are infected with Helicobacter pylori, found primarily in the stomach. The majority never show any symptoms, but just over ten per cent develop gastric ulcers, while around one per cent develop gastric adenocarcinoma. Without antibiotics the body is unable to rid itself of the bacteria.
"Helicobacter pylori inhibits our immune defence, preventing it from attacking the bacteria with sufficient strength, despite an immune response being activated," says biologist Malin Hansson, the author of the thesis.
When an immune response is initiated a specific type of cell migrates to the lymph nodes to activate new immune cells, telling them where they need to go to tackle the infection. Infection with Helicobacter pylori prevents many of these cells from reaching their intended destination.
"Helicobacter pylori causes immune cells to accumulate in tissue. Many of the cells that ought to collect more new immune cells stop at these accumulations and begin activating these instead, leading to chronic inflammation, which we believe benefits Helicobacter pylori," says Malin Hansson.
This thesis also paves the way for a future vaccine against gastric adenocarcinoma. Previous research has shown that many infected patients with gastric adenocarcinoma have low levels of a specific type of antibody in tissue, even though Helicobacter pylori normally causes unusually high levels of antibodies. These antibodies should therefore be able to protect against this form of cancer. For the first time in samples taken from humans Malin Hansson has been able to show that these antibodies are attracted to tissue by a signal substance called MEC.
"If these antibodies really can protect against development of gastric adenocarcinoma, it would be possible to develop a vaccine that increases MEC expression and thus the number of antibodies present in tissue," says Malin.
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences