More specifically, there has been considerable attention around near-infrared (NIR) light as an ideal method to stimulate nanoparticles from outside the body. NIR is minimally absorbed by skin and tissue, has the ability to penetrate deep tissue in a noninvasive way and the energy from NIR light can be converted to heat by gold nanomaterials for effective thermal ablation of diseased tissue.
One DNA strand is attached to the gold nanorod and the complementary strand is attached to a stealth layer and a homing molecule that keeps the system under the radar of the immune system while targeting it directly to cancer cells. When the DNA strands come together, the targeted gold nanorod is formed and the double stranded DNA serves as the scaffold for binding the chemotherapy drug, doxorubicin, which can be released in response to NIR light that concurrently results in generation of heat by the gold nanorods.
"This new platform is comprised of three distinct functional components and each plays a role in contributing to the triple punch of triggered thermotherapy, controlled doxorubicin release, and cancer cell targeting," explained Zeyu Xiao, PhD, a postdoctoral fellow at BWH and lead author of this study.
To demonstrate the robust capability of this nanorod system, Farokhzad and colleagues used a pre-clinical model to evaluate the in vivo anti-tumor efficacy in two different tumor models and four different groups with different drug regiments, each group varying in weight and tumor size. Researchers administrated an injection of the novel, self-assembled nanoparticle and then 10 minutes post-injection, the tumors were irradiated using NIR light that activated the nanoparticle using the gold nanorod and created heat. The results showed that this platform successfully delivered heat and anti-cancer drugs and synergistically eradicated tumors.
"Thermal ablation is already commonly used in cancer treatment," said Dr. Farokhzad. "What is extremely exciting about this platform is that we are able to selectively target cancer cells and then hit the tumor twice: first with a controlled release of a chemotherapy drug and then secondly with triggered induction of heat from the activation of the gold nanorod. And all this can be done noninvasively."
Researchers acknowledge that more research is necessary in other pre-clinical models before testing the safety and efficacy of this platform in human clinical trials.
This research was supported by the National Institutes of Health under grant number CA151884 and the David Koch-Prostate Cancer Foundation Program in Cancer Nanotherapeutics. O.C.F. has financial interest in BIND Biosciences, Selecta Biosciences, and Blend Therapeutics, biopharmaceutical companies that are developing therapeutic nanoparticles.
Lori J. Schroth | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering