Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Why fish oils help and how they could help even more

29.10.2009
New research from Queen Mary, University of London and Harvard Medical School has revealed precisely why taking fish oils can help with conditions like rheumatoid arthritis.

In a paper published in Nature today*, researchers describe how the body converts an ingredient found in fish oils into another chemical called Resolvin D2 and how this chemical reduces the inflammation that leads to a variety of diseases.

The research also suggests that Resolvin D2 could be the basis for a new treatment for diseases including sepsis, stroke and arthritis. Unlike other anti-inflammatory drugs, this chemical does not seem to suppress the immune system.

The researchers, who were funded by the Arthritis Research Campaign, the Wellcome Trust and the National Institutes of Health, looked at a particular ingredient of fish oils called DHA. They were able to show how the body converts DHA into Resolvin D2 and discover its exact chemical structure.

Mauro Perretti, Professor of Immunopharmacology at Queen Mary, University of London, led the UK team. He said: "We have known for some time that fish oils can help with conditions like arthritis which are linked to inflammation. What we've shown here is how the body processes a particular ingredient of fish oils into Resolvin D2. We've also looked in detail at this chemical, determining at least some of the ways it relieves inflammation. It seems to be a very powerful chemical and a small amount can have a large effect."

"This research is important because it explains at least one way in which fish oils can help in different types of arthritis. We can also work on this chemical and see if it can be used not only to treat or even prevent arthritis, but also as a possible treatment for a variety of other diseases associated with inflammation."

Arthritis, and many other diseases, are caused by inflammation. This means that the body's natural defences against infections are mistakenly directed at healthy tissue.

Previous research has shown that a crucial step in this process occurs when white blood cells, called leukocytes, stick to the inner lining of the blood vessels, called the endothelium.

Researchers studied these blood cells and how they interact with the endothelium in the lab. When they added Resolvin D2 they found that the endothelial cells produced small amounts of nitric oxide, which acts as a chemical signal discouraging the white blood cells from sticking to the endothelial cells and preventing inflammation.

* Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Spite et al, Nature, DOI: 10.1038/nature08541

For media enquiries, please contact Kerry Noble in the communications office at Queen Mary, University of London on 020 7882 7910 or 07932 640 759.

Notes to editors

DHA (docosahexaenoic acid) is an omega-3 fatty acid. Fish oils are a rich source of DHA.

One of the authors of this study, Dr Lucy Norling is the recipient of an Arthritis Research Campaign Foundation Fellowship. She studied a PhD at Queen Mary, University of London and now divides her time between Queen Mary and Brigham and Women's Hospital, Harvard Medical School.

The Arthritis Research Campaign is the UK's fourth largest medical research charity, which raised more than £34m from public donations over the past 12 months to fund its extensive research and education portfolio. Its aims are to improve the lives of people with arthritis through high quality research into the cause, treatment and cure of arthritis and related conditions, translating the outcomes of research for the direct benefit of patients, educating health professionals and providing information on arthritis to patients and the general public. www.arc.org./uk

The Wellcome Trust is the largest charity in the UK. It funds innovative biomedical research, in the UK and internationally, spending over £600 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. http://www.wellcome.ac.uk

Kerry Noble | EurekAlert!
Further information:
http://www.qmul.ac.uk

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>