Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New findings on troubling side effects of Parkinson’s medication

One in every 100 elderly people suffers from Parkinson’s disease, a disease of the nervous system with symptoms including stiffness and shaking.

The standard medication used to treat Parkinson’s is Levodopa, a drug that initially has major benefits but can later also produce serious side effects in the form of involuntary, jerky movements. A research group at Lund University has now found a way to study what it is in the brain that causes these side effects.

The jerky and unpredictable movements that form the side effects of the medication are known as dyskinesias. It is clear that dyskinesias are caused by long-term use of Levodopa, but researchers have been divided on the exact details of the mechanisms behind them and there has been no good way to study them in laboratory animals. This is what the Lund researchers have now developed.

“We use a harmless virus that introduces a small gene into the nerve cells. In a process involving several stages, the gene causes the nerve cells to stop producing dopamine, without destroying them”, explains Ayse Ulusoy. She has recently defended a thesis that includes these studies.

In a patient with Parkinson’s disease, the nerve cells that produce dopamine die. However, at the same time other cells in the brain also suffer changes. This makes it very difficult to find out which of these changes causes the dyskinesias.

In the new model system that Ayse and her colleagues have developed, the laboratory rats’ nerve cells otherwise function normally. This is what makes it possible to see what causes the dyskinesias, the unpleasant side effect of the Parkinson’s medication.

“We have seen that they are linked to the ‘fibre terminals’ on the nerve cells that should release dopamine. These new findings open up great opportunities to improve the treatment of Parkinson’s disease in the long run”, says neurologist Gurdal Sahin.

Ayse Ulusoy and Gurdal Sahin are members of Professor Deniz Kirik’s research group at Lund University.

The group has recently published its results in the journal PNAS (Proceedings of the National Academy of Sciences). Deniz Kirik believes that the study will be of great international interest, because Parkinson’s disease exists around the world and the side effects of the medication have long been seen as a very serious problem.

For more information, please contact Deniz Kirik, +46 (0)733 822586 or

Ingemar Björklund | idw
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>