Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New findings highlight the challenges of managing blood clotting in cancer patients

01.10.2012
New findings that highlight the challenges of managing thromboembolic events in patients being treated for cancer were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.
Venous thromboembolism causes symptoms in about 3 to 4% of cancer patients whose chemotherapy drugs are delivered via a central venous catheter, comments Dr. Fausto Roila, from Medical Oncology Department, Terni, Italy, Chair of the ESMO 2012 Supportive Care Track. "When asymptomatic patients are considered, these events affect about 12-18% of patients who have central venous catheters."

Efficacy of anticoagulation for cancer patients suggests guidelines should be reconsidered

Anticoagulants are effective for preventing deep vein thrombosis in cancer patients who have a central venous catheter in place for the delivery of chemotherapy, the results of a new French study reveal.

The risk of deep vein thrombosis (DVT) is higher among cancer patients than among the general population. Furthermore, patients undergoing chemotherapy often have central venous access devices implanted. These devices are associated with deep vein thrombosis, which can lead to a pulmonary embolism and in some cases, death. But whether an anticoagulant prophylaxis is needed for patients with cancer with a central venous catheter is a controversial subject.

Dr Sandrine Lavau-Denes, from Centre Hospitalier Universitaire à Limoges, and colleagues performed a phase III prospective, randomized trial in 407 patients and found that anticoagulation significantly reduced the incidence of catheter-related DVT.

"The current guidelines of the American Society of Clinical Oncology, American College of Chest Physicians, and the French National Federation of the League of Centers against Cancer do not recommend prophylactic anticoagulant treatment for cancer outpatients," Dr Lavau-Denes says. "In recent studies and meta-analyses, results are still contradictory, perhaps because of the heterogeneity of the screened patients. We think that these new results should lead to a new reflection."

Dr Fausto Roila, who was not involved in the study, said: "The incidence of CVC-related thrombosis was significantly lower with the two anticoagulant drugs [8.1% (22/272) versus 14.8% (20//135), respectively]." Dr. Roila noted however that the study has some limitations, among these the fact that it is a single-centre study requiring 11 years to be completed. Therefore, "the results of this study should be confirmed by other double-blind, randomized clinical trials, before changing the actual recommendations".

Related studies presented at ESMO 2012
Real-world analysis shows risks and costs of venous thromboembolic events with chemotherapy

For patients with breast and prostate cancer, the risk of venous thromboembolism within the first months after initiation of chemotherapy is about 4% and almost doubles at 12 months, a new US analysis shows. The study used the US IMPACT claims database to retrospectively identify 34,144 patients with breast and prostate cancer.

Almost 20% of patients receiving cisplatin-based chemotherapy experience thromboembolic events

A retrospective analysis of 141 cancer patients treated with cisplatin-based chemotherapy finds that 19.1% experienced a thromboembolic event, including deep vein thrombosis, pulmonary embolism and arterial thrombosis. Patients with gastric and pancreatic cancers had the highest incidence of events. It is important to carry out randomized studies to conclude the need for prophylaxis of thromboembolic events in these patients, authors say.

ESMO PRESS OFFICE | EurekAlert!
Further information:
http://www.esmo.org

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>