Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New findings highlight the challenges of managing blood clotting in cancer patients

01.10.2012
New findings that highlight the challenges of managing thromboembolic events in patients being treated for cancer were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.
Venous thromboembolism causes symptoms in about 3 to 4% of cancer patients whose chemotherapy drugs are delivered via a central venous catheter, comments Dr. Fausto Roila, from Medical Oncology Department, Terni, Italy, Chair of the ESMO 2012 Supportive Care Track. "When asymptomatic patients are considered, these events affect about 12-18% of patients who have central venous catheters."

Efficacy of anticoagulation for cancer patients suggests guidelines should be reconsidered

Anticoagulants are effective for preventing deep vein thrombosis in cancer patients who have a central venous catheter in place for the delivery of chemotherapy, the results of a new French study reveal.

The risk of deep vein thrombosis (DVT) is higher among cancer patients than among the general population. Furthermore, patients undergoing chemotherapy often have central venous access devices implanted. These devices are associated with deep vein thrombosis, which can lead to a pulmonary embolism and in some cases, death. But whether an anticoagulant prophylaxis is needed for patients with cancer with a central venous catheter is a controversial subject.

Dr Sandrine Lavau-Denes, from Centre Hospitalier Universitaire à Limoges, and colleagues performed a phase III prospective, randomized trial in 407 patients and found that anticoagulation significantly reduced the incidence of catheter-related DVT.

"The current guidelines of the American Society of Clinical Oncology, American College of Chest Physicians, and the French National Federation of the League of Centers against Cancer do not recommend prophylactic anticoagulant treatment for cancer outpatients," Dr Lavau-Denes says. "In recent studies and meta-analyses, results are still contradictory, perhaps because of the heterogeneity of the screened patients. We think that these new results should lead to a new reflection."

Dr Fausto Roila, who was not involved in the study, said: "The incidence of CVC-related thrombosis was significantly lower with the two anticoagulant drugs [8.1% (22/272) versus 14.8% (20//135), respectively]." Dr. Roila noted however that the study has some limitations, among these the fact that it is a single-centre study requiring 11 years to be completed. Therefore, "the results of this study should be confirmed by other double-blind, randomized clinical trials, before changing the actual recommendations".

Related studies presented at ESMO 2012
Real-world analysis shows risks and costs of venous thromboembolic events with chemotherapy

For patients with breast and prostate cancer, the risk of venous thromboembolism within the first months after initiation of chemotherapy is about 4% and almost doubles at 12 months, a new US analysis shows. The study used the US IMPACT claims database to retrospectively identify 34,144 patients with breast and prostate cancer.

Almost 20% of patients receiving cisplatin-based chemotherapy experience thromboembolic events

A retrospective analysis of 141 cancer patients treated with cisplatin-based chemotherapy finds that 19.1% experienced a thromboembolic event, including deep vein thrombosis, pulmonary embolism and arterial thrombosis. Patients with gastric and pancreatic cancers had the highest incidence of events. It is important to carry out randomized studies to conclude the need for prophylaxis of thromboembolic events in these patients, authors say.

ESMO PRESS OFFICE | EurekAlert!
Further information:
http://www.esmo.org

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>