Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Filtering Donor Blood Reduces Heart, Lung Complications

23.06.2010
Researchers at the University of Rochester Medical Center (URMC) have discovered yet another reason to filter the foreign white cells from donor blood: the resulting blood product is associated with dramatically fewer cardiopulmonary complications for patients who received a transfusion.

The study is published online in the journal, Transfusion. It is the latest in a large body of work led by Neil Blumberg, M.D., who for 25 years has been investigating the benefits of filtering or washing blood to create safer, simpler approaches to transfusion therapy.

The observational study was conducted during the seven years before and after 2000, when the URMC introduced universal leukoreduction, a process that filters the white cells from blood to be used for transfusions. Researchers looked at the number of reports of transfusion reactions during the 14-year period, and divided them by the total number of blood components transfused (778, 559).

Rates of acute, transfusion-related lung injury dropped 83 percent in the years after filtering took place, and transfusion-associated circulatory overload declined 49 percent, when compared to the rates prior to the year 2000. Both conditions are rare, but are among the most common causes of death following a transfusion.

“These data are very exciting because we described two unexpected and unexplained associations between adverse reactions and leukoreduction, “Blumberg said. “However, our observations do not prove cause and effect, and therefore require further investigation before we can say with certainty that leukoreduction is responsible for so many fewer cardiopulmonary complications.”

The Centers for Disease Control and Prevention is introducing a new blood surveillance system to track severe transfusion reactions, Blumberg said, which should provide more detailed information to support or refute the URMC study.

About five million people a year in the United States receive transfusions to replenish blood lost during surgery, serious injury or illness. While transfusions can be life-saving, they also lead to health complications.

In previous studies, Blumberg’s team has shown that the odds of post-surgical infection and death are greatly reduced by leukoreduction. White cells from donor blood can attack the immune system of the blood recipient; removing them diminishes the chances of an inflammatory response or infection, according to Blumberg’s research.

Transfusion-related lung injury is believed to happen when antibodies or other molecules from the donor’s white blood cells or plasma react in an adverse way with the recipient’s white blood cells. Circulatory overload is presumed to occur when the volume of blood given in a transfusion is too much for the recipient’s cardiovascular system. Researchers hypothesized that leukoreduction, which removes the white cells, would reduce those complications.

In 1998 Strong Memorial Hospital, a 739-bed facility owned by the URMC, became one of the first hospitals in the nation to use leukoreduced blood during heart surgeries. Two years later Strong extended its leukoreduction practices to all patients. Work done at URMC also has supported keeping transfusions to an absolute minimum. Blumberg’s evidence-based stance on the judicious use of transfusions and safer techniques has contributed greatly to the national and international dialogue on reducing in-hospital infections rates and controlling costs.

No extramural funding supported this study, although two researchers receive partial salary support from National Institutes of Health grants. Data retrieval and analysis were conducted as part of a larger quality assurance initiative.

Co-authors are: Joanna M. Heal, Kelly F. Gettings, Richard P. Phipps, Debra Masel, Majed A. Refaai, Scott A. Kirkley, and L. Benjamin Fialkow, from the Transfusion Medicine Unit and Department of Pathology and Laboratory Medicine, at the University of Rochester Medical Center. Phipps is also a professor of Environmental Medicine.

For Media Inquiries:
Leslie Orr
(585) 275-5774
Email Leslie Orr

Leslie Orr | EurekAlert!
Further information:
http://www.rochester.edu

Further reports about: Medical Wellness Strong Transfusion blood cell blood flow white blood cell

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>