The study is published online in the journal, Transfusion. It is the latest in a large body of work led by Neil Blumberg, M.D., who for 25 years has been investigating the benefits of filtering or washing blood to create safer, simpler approaches to transfusion therapy.
The observational study was conducted during the seven years before and after 2000, when the URMC introduced universal leukoreduction, a process that filters the white cells from blood to be used for transfusions. Researchers looked at the number of reports of transfusion reactions during the 14-year period, and divided them by the total number of blood components transfused (778, 559).
Rates of acute, transfusion-related lung injury dropped 83 percent in the years after filtering took place, and transfusion-associated circulatory overload declined 49 percent, when compared to the rates prior to the year 2000. Both conditions are rare, but are among the most common causes of death following a transfusion.
“These data are very exciting because we described two unexpected and unexplained associations between adverse reactions and leukoreduction, “Blumberg said. “However, our observations do not prove cause and effect, and therefore require further investigation before we can say with certainty that leukoreduction is responsible for so many fewer cardiopulmonary complications.”
The Centers for Disease Control and Prevention is introducing a new blood surveillance system to track severe transfusion reactions, Blumberg said, which should provide more detailed information to support or refute the URMC study.
About five million people a year in the United States receive transfusions to replenish blood lost during surgery, serious injury or illness. While transfusions can be life-saving, they also lead to health complications.
In previous studies, Blumberg’s team has shown that the odds of post-surgical infection and death are greatly reduced by leukoreduction. White cells from donor blood can attack the immune system of the blood recipient; removing them diminishes the chances of an inflammatory response or infection, according to Blumberg’s research.
Transfusion-related lung injury is believed to happen when antibodies or other molecules from the donor’s white blood cells or plasma react in an adverse way with the recipient’s white blood cells. Circulatory overload is presumed to occur when the volume of blood given in a transfusion is too much for the recipient’s cardiovascular system. Researchers hypothesized that leukoreduction, which removes the white cells, would reduce those complications.
In 1998 Strong Memorial Hospital, a 739-bed facility owned by the URMC, became one of the first hospitals in the nation to use leukoreduced blood during heart surgeries. Two years later Strong extended its leukoreduction practices to all patients. Work done at URMC also has supported keeping transfusions to an absolute minimum. Blumberg’s evidence-based stance on the judicious use of transfusions and safer techniques has contributed greatly to the national and international dialogue on reducing in-hospital infections rates and controlling costs.
No extramural funding supported this study, although two researchers receive partial salary support from National Institutes of Health grants. Data retrieval and analysis were conducted as part of a larger quality assurance initiative.
Co-authors are: Joanna M. Heal, Kelly F. Gettings, Richard P. Phipps, Debra Masel, Majed A. Refaai, Scott A. Kirkley, and L. Benjamin Fialkow, from the Transfusion Medicine Unit and Department of Pathology and Laboratory Medicine, at the University of Rochester Medical Center. Phipps is also a professor of Environmental Medicine.For Media Inquiries:
Leslie Orr | EurekAlert!
TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute
Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences