Thirty-seven million people are admitted to the emergency room with traumatic injury each year, and these injuries are a leading cause of death in the US. Two major reasons why traumatic injury is so deadly are loss of blood (hemorrhage) and a clinical condition called sepsis.
Sepsis occurs when molecules released into the bloodstream to fight an injury or infection trigger inflammation throughout the body. Inflammation is necessary for maintaining good health – without inflammation, wounds and infections would never be controlled or heal. However, persistent and constant inflammation often results in organ dysfunction or damage, leading to patient death – 28 to 50 percent of people who suffer from sepsis die from the condition.
For years, Feinstein Institute scientists have been researching ways to treat sepsis by halting persistent and constant inflammation. As a result of this effort, Ping Wang, MD, director for the Laboratory of Surgical Research and head of the Center for Translational Research at the Feinstein Institute, and his colleagues discovered that a protein called cold-inducible RNA-binding protein (CIRP) is increased and released into the bloodstream in response to hemorrhagic shock and sepsis. When CIRP triggers inflammation, it contributes to damage of organs in the body. Dr. Wang hypothesized that if CIRP activity is blocked, causing reduced inflammation, then patient survival will improve. To test this theory, he and his colleagues observed that treatment with an antibody against CIRP significantly increased survival rates during hemorrhage and sepsis in preclinical studies.
"In this study, we identified a small peptide that can be potentially developed as anti-CIRP compound," said Dr. Wang. "What this means for patients is that we may have discovered a molecule that could be used in the future to treat hemorrhage and sepsis and save many lives."
"There's a great need for new ways to diagnose and treat sepsis," said Sarah Dunsmore, PhD, of the National Institute of Health's National Institute of General Medical Sciences, which partially funded the research. "By targeting molecules such as CIRP, which are part of the body's normal response to stress, we may be able to tailor each patient's treatment based on how much damage has already been done and which organs are at risk of failure. Dr. Wang's work may also provide insight into how healthy cells survive extreme temperatures and other stressors, information that might be harnessed to treat a variety of disorders."About The Feinstein Institute for Medical Research
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Process Engineering
23.01.2017 | Physics and Astronomy
23.01.2017 | Life Sciences