New research in The Journal of Physiology connects low aerobic capacity to another serious condition – non-alcoholic fatty liver disease (NAFLD) – and suggests that the resulting liver problems play a crucial step developing obesity-related illnesses.
Sufferers of NAFLD accumulate fat in their livers and have high levels of fat in their blood, amplifying the risk-factors of obesity. The disease leads to a form of liver damage called fibrosis, similar to the results of alcohol abuse. "Fatty liver disease will be the next big metabolic disorder associated with obesity and inactivity," said the study's lead author John Thyfault of the University of Missouri. "It also is a significant contributor to type 2 diabetes."
To test the link between fitness and fatty liver disease, Dr Thyfault's team selectively bred two groups of rats with very different levels of intrinsic aerobic capacity. After 17 generations of careful breeding, their 'unfit' rats could run an average of just 200m compared to over 1500m achieved by the average 'fit' rat.
The effect on the rats' livers was devastating. At 25 weeks old, the unfit group were displaying clear symptoms of NAFLD – weakened mitochondria (the cell's powerhouses), poor fat processing power, high fat retention and other abnormalities. By the end of their natural lives, the rats' livers had sustained damage including fibrosis (the precursor to cirrhosis) and unexpected cell death.
In contrast, the 'fit' group enjoyed heathly livers throughout their lifespans – despite the fact that neither group was getting any real exercise.
The team's findings provide the first biochemical links between low aerobic fitness and fatty liver disease, and have lead the authors to suggest that NAFLD could potentially be treated or prevented by a suitable exercise program.
"Your personal aerobic fitness is not something you will see in the mirror but it is an important predictor of your long-term health," Thyfault said. "The most important part of physical activity is protecting yourself from diseases that can be fatal or play a significant role in increasing the risk factors for other metabolic diseases."
Melanie Thomson | EurekAlert!
Further reports about: > Diabetes > Fatty liver disease > NAFLD > Poor aerobic fitness > aerobic capacity > alcohol abuse > cirrhosis > fatty liver > fibrosis > heart disease > liver disease > metabolic disorder > mitochondria > non-alcoholic fatty liver disease > risk factor > strokes > type 2 diabetes
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences