It’s rare, but sometimes things go wrong. In a matter of minutes, patients’ skin can turn red or blotchy white and the injected area becomes painful. Vital blood supply to the face is restricted and if untreated, parts of the tissue will die. That scenario is irreversible and can leave deep scars.
Siavash Yousefi, U of Washington
This image shows a mouse ear after a successful cosmetic filler injection. The filler, in green, rests in the tissue without blocking the blood vessels and veins.
Physicians haven’t been able to pinpoint why this happens because until now it was difficult to see how the injected fluid, or filler, behaves in facial tissue.
New imaging technology from University of Washington engineers allows scientists to analyze what happens within the smallest blood vessels during an injection. This finding could be used to prevent accidents during procedures and help clinicians reverse the ill effects if an injection doesn’t go as planned.
“Filler-induced tissue death can be a really devastating complication for the patient and provider,” said Shu-Hong (Holly) Chang, a UW assistant professor of ophthalmology specializing in plastic and reconstructive surgery. “This noninvasive imaging technique provides far better detail than I’ve ever seen before and helped us figure out why this is happening.”
Using this technology, Chang and her team saw that complications arose when filler was inadvertently injected into the bloodstream rather than in the intended soft tissues of the face. The gel builds up in a vessel, blocking blood movement and oxygen exchange. The team tested this in the ears of mice, which offer a model of what can happen in the blood vessels of a human face, Chang said.
She presented the results in November at the annual meeting of the American Society of Ophthalmic Plastic and Reconstructive Surgery showing that filler injections into blood vessels are most likely the cause of tissue death and other complications associated with the cosmetic procedure.
Ruikang Wang, a UW professor of bioengineering, and his lab pioneered this fine-resolution imaging, called optical microangiography. It can turn out 3-D images of the body’s vascular network by shining a light onto the tissue without touching it or adding any fluorescent dyes.
“We can visualize how blood responds to the cosmetic filler gel, even looking at the responses of each individual vessel. No other technique can provide this level of scrutiny,” Wang said.
The optical imaging technique operates on the same concept as ultrasound, which leverages changes in sound to detect structures. This technique instead uses light to repeatedly scan tissue cross-sections, delineating unmoving pieces (surrounding tissues) from moving segments (blood cells in vessels). Researchers compare image frames and piece together the complex visual web.
This technology can see blood vessels as small as 5 microns in diameter. Capillaries, the smallest vessels in our bodies, are about 7 microns in diameter and a red blood cell is usually 3 to 5 microns wide.
“Our niche is imaging the microvascular system,” said team member Siavash Yousefi, a UW graduate student in bioengineering. Other applications of the technology include analyzing how wounds heal, tracking what happens during strokes and traumatic brain injuries, and imaging human eyes to study diseases such as glaucoma and macular degeneration.
Cosmetic filler procedures have surged worldwide in recent years, particularly in Europe and Asia. In 2012 in the U.S. about 2 million procedures were performed. Up to 800 patients reportedly suffered serious complications, including potentially permanent disfigurement.
During the procedure, a practitioner injects the gel-like solution, often a natural substance called hyaluronic acid, multiple times into a person’s face. Restriction of blood to the tissues, called ischemia, often doesn’t show up until later, when the patient develops pain and sees changes on the surface of the skin, meaning the tissue is dying.
Some practitioners suggest using massage and warm compresses to treat the area, while others tell patients to take aspirin, but the field doesn’t have a standard course of action for treating these complications, Chang said. She has been called in for several emergencies to treat other practitioners’ patients who show signs of a failed procedure. This can lead to tissue death and even blindness if the affected area is near the eyes.
With this new understanding, practitioners can try to reverse the effect of vascular blockage by injecting an enzyme that dissolves hyaluronic acid fillers. The research team is now testing all types of available cosmetic fillers to see if their results hold on each brand and evaluating new treatments for reversing procedure complications.
“Our lab is trying to develop novel and clinically useful biomedical imaging techniques for early diagnosis, treatment and management of human diseases. Using this technology to better understand facelift complications is a perfect example that fulfills this mission,” Wang said.
The research was funded in part by the organization Research to Prevent Blindness and a Latham Vision Research Innovation Award.
For more information, contact Yousefi at firstname.lastname@example.org or 541-602-9592; Chang at email@example.com or 206-897-4611; and Wang at firstname.lastname@example.org or 206-616-5025.
Michelle Ma | EurekAlert!
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy