EyeBrain, a company developing medical devices for the early diagnosis of neurological diseases, announces today that its EyeBrain Tracker device is being used in a clinical trial exploring the dyskinesia induced by treating patients suffering from idiopathic Parkinson’s disease with levodopa.
The endpoint of the trial is to find biomarkers for the late-onset complications of a treatment regime using levodopa (BIODYS). This compound, which is naturally transformed into dopamine in the brain, is one of the only drugs available for slowing the effects of Parkinson’s disease. However, over time, it induces dyskinesia in these patients, which takes the form of abnormal movements primarily affecting the face (tongue, lips, jaw) and extending as far as the arms and legs.
Altogether, 30 people will be enrolled on the trial. Half of them will be Parkinson’s sufferers who have been treated with levodopa and have developed dyskinesia, while the other half will consist of healthy subjects who will be used as a control group.
The trial is being sponsored and financed by Bordeaux University Hospital and was set up by professor Jean-François Tison, a neurologist attached to the CNRS Physiopathology of Parkinsonian syndromes unit at the University of Bordeaux Two (the Institute of Neurodegenerative Diseases, CNRS UMR 5293E, Bezard). The EyeBrain Tracker device is being funded under the joint 2007-2013 State-Region Plan (Aquitaine Regional Council and the FEDER fund).
“Patients suffering from idiopathic Parkinson’s disease will undergo an acute test as part of a pre-operational assessment for stimulating the deep recesses of the brain,” explained professor Tison. The motricity effects of the treatment will be evaluated by measuring the speed of eye movements with the help of the EyeBrain Tracker.
“We will see whether levodopa modifies the parameters of blinking in a way that is correlated with the improvement in motricity,” said professor Tison. “Using the EyeBrain Tracker enables us to measure the motricity effect through eye movements, since the blinking parameters are also linked to the patient’s general motricity. The patient’s response to this trial is also a predictor of their reaction to the neurosurgery that will follow.”
The EyeBrain Tracker, which is already used in the early diagnosis of Parkinsonian syndromes, such as progressive supra-nuclear paralysis (PSP), cortico-basal degeneration (CBD) and multiple systems atrophy (MSA), is thus continuing to broaden its fields of application. It is now playing an important role in clinical research into other neurological diseases, such as multiple sclerosis, and is a valuable aid in the early diagnosis and follow-up of these diseases.
“We are delighted to know that the EyeBrain Tracker is playing a part in a clinical trial targeting idiopathic Parkinson’s,” said the chairman of EyeBrain, Serge Kinkingnéhun. “This forms part of our goal of making the benefits of eye motricity available to a larger number of people suffering from neurological pathologies.”
Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s. In western countries it affects 0.3 per cent of the general population. Its prevalence increases with age, reaching one per cent in the over-60s, and as much as four per cent in the over-80s. There are 100,000 sufferers in France and 8,000 new cases are diagnosed each year.About EyeBrain
The Mobile EyeBrain Tracker (EBT) comes as a complete solution including headphones, a computer with two screens and stimulation and analysis software. It is already being used routinely in hospitals to help with the early characterization of Parkinsonian syndromes. Studies are also underway for the diagnosis of multiple sclerosis (MS).
The Mobile EBT is the only device of its kind in the world to have obtained CE marking. The company has ISO 9001 and ISO 13485 certification.
EyeBrain, which is based in the Paris suburb of Ivry-sur-Seine, was founded in 2008 and currently employs 15 people. It has raised funding of EUR 1.2 million from the CapDecisif and G1J venture capital funds and already generates revenues through the sale of the EyeBrain Tracker. It is engaged in collaborations with the French National Health and Medical Research Institute (INSERM), the French National Scientific Research Center (CNRS), Paris University Hospitals group, the University of Paris-Descartes and the French Brain and Spinal Cord Institute.For further information about the company, go to: http://www.eye-brain.com
Lucie Nguyen | Andrew Lloyd & Associates
Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
24.07.2017 | Power and Electrical Engineering
24.07.2017 | Materials Sciences
24.07.2017 | Materials Sciences