Certain personality traits heighten susceptibility to psychiatric disorders. Therefore a research team at Umeå University wanted to study whether this patient group had any susceptibility factors that could explain the development of their disorder.
The patient group is distinguished by being anxious and pessimistic, with a weak sense of self, which is common in many psychiatric disorders. What was special about this group was that they stood out as persistent, ambitious, and pedantic individuals.
Being ambitious, fastidious, and overachieving also appears to make a person more prone to exhaustion syndrome. According to Agneta Sandström’s dissertation, individuals with exhaustion syndrome demonstrate impaired memory and attention capacity as well as reduced brain activity in parts of the frontal lobes. Regulation of the stress hormone cortisol is also impacted in the group, with altered sensitivity in the hypothalamic-pituitary-adrenal axis (HPA axis).
The dissertation addresses whether it is possible to use neuropsychological tests to confirm and describe the cognitive problems reported by patients suffering from exhaustion syndrome. Above all, patients demonstrate problems regarding attention and working memory. Patients were also asked to perform working memory tests while lying in a functional magnetic resonance camera that measures the brains activity patterns. Exhaustion syndrome patients proved to have a different activity pattern in the brain when they performed a language test of their working memory, and they also activate parts of the frontal lobe less than healthy subjects and a group of patients who had recently developed depression.
The HPA axis in the patient group shows reduced sensitivity in the pituitary, with less secretion of adrenocorticotropic hormone (ACTH) following stimulation with corticotropin (CRH), as well as heightened sensitivity in the adrenal cortex, with increased release of cortisol in relation to the amount of ACTH secreted. There is also a difference in the diurnal rhythm of corisol, with the patients presenting a flatter secretion curve than the other two groups. The researchers could not detect any reduction in the volume of the hippocampus in the patient group. The proportion of individuals with measurable levels of the pro-inflammatory cytokine interleukin 1 is higher in the patient group.
In summary, the studies indicate that there is an association between personality, general health, cognitive ability, and neuroendocrinal dysfunction in exhaustion syndrome. The cognitive problems reflected in the test scores are also mirrored in a different activity pattern in the brain for patients with exhaustion depression. Agneta Sandström has also found support for there being similarities with clinical depression, but with well-defined differences.
Agneta Sandström can be reached at phone: +46 (0)63-15 49 16; mobile +46 (0)70-327 93 90; e-mail email@example.comPressofficer Bertil Born; firstname.lastname@example.org; +46-703 886 058
Bertil Born | idw
Cells adapt ultra-rapidly to zero gravity
28.02.2017 | Universität Zürich
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
28.02.2017 | Health and Medicine
28.02.2017 | Earth Sciences
27.02.2017 | Materials Sciences