The enzyme protein found naturally in the body alleviated pain eight times more effectively than morphine. Research findings are published this week as the cover story of the esteemed Neuron journal.
Professor Pirkko Vihko from the Department of Biological and Environmental Sciences of the University of Helsinki has conducted research on the Prostatic Acid Phosphatase (PAP) enzyme for more than 30 years. As the name indicates, the prostate contains plenty of this enzyme.
Last year, Vihko's research team described the membrane form of the enzyme and showed that it is present not only in the prostate, but in many other cells and organs as well. The PAP enzyme exists, for example, in pain-sensing nerves, but it has disappeared from damaged nerves.
For the research project presented in the Neuron journal, Vihko and her team prepared a knockout mouse model with the PAP enzyme knocked out. Together with Mark Zylka's team from the University of North Carolina they showed that these mice had an increased sensitivity for pain caused by inflammation and neural damage. The reason for the sensitivity was the lack of the PAP enzyme. Enzyme protein replacement treatment removed pain effectively – eight times more so than morphine. Clinical research will begin next.
Research teams also determined the mechanism that the acid phosphatase of the prostate uses to regulate pain alleviation. In an organism, the enzyme generates adenosine that controls the experience of pain through the adenosine receptor. Vihko’s team will prepare new publications that describe the entirely new effective areas of the enzyme.
Kirsikka Mattila | alfa
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences