Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme protein eight times more effective against pain than morphine

09.10.2008
More people suffer from pain than from heart diseases, diabetes or cancer combined. Research teams at the University of Helsinki and the University of North Carolina have discovered a new powerful painkiller that has shown no side effects in mouse testing.

The enzyme protein found naturally in the body alleviated pain eight times more effectively than morphine. Research findings are published this week as the cover story of the esteemed Neuron journal.

Professor Pirkko Vihko from the Department of Biological and Environmental Sciences of the University of Helsinki has conducted research on the Prostatic Acid Phosphatase (PAP) enzyme for more than 30 years. As the name indicates, the prostate contains plenty of this enzyme.

Last year, Vihko's research team described the membrane form of the enzyme and showed that it is present not only in the prostate, but in many other cells and organs as well. The PAP enzyme exists, for example, in pain-sensing nerves, but it has disappeared from damaged nerves.

For the research project presented in the Neuron journal, Vihko and her team prepared a knockout mouse model with the PAP enzyme knocked out. Together with Mark Zylka's team from the University of North Carolina they showed that these mice had an increased sensitivity for pain caused by inflammation and neural damage. The reason for the sensitivity was the lack of the PAP enzyme. Enzyme protein replacement treatment removed pain effectively – eight times more so than morphine. Clinical research will begin next.

Research teams also determined the mechanism that the acid phosphatase of the prostate uses to regulate pain alleviation. In an organism, the enzyme generates adenosine that controls the experience of pain through the adenosine receptor. Vihko’s team will prepare new publications that describe the entirely new effective areas of the enzyme.

Kirsikka Mattila | alfa
Further information:
http://www.neuron.org/

Further reports about: Cancer Diabetes Enzym Enzyme protein Neuron Painkiller morphine prostate

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>