Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Effects of celiac disease on bone mineral density are pronounced in lumbar spine than femoral neck

Patients with celiac disease are more than 4.5 times more likely to develop osteoporosis compared to healthy people in an age and gender matched cohort with no identifiable risk factors for osteoporosis, according to a study presented today at the EULAR 2011 Annual Congress.

The British study of 1,030 people compares the extent of bone mineral density (BMD)* loss – a common measure of osteoporosis – in two physical locations in the body. The results demonstrated that the mean BMD of the lumbar spine in patients with coeliac disease was significantly different when compared to the control group (1.79 (95% CI 1.32, 2.44)), however not for the femoral neck vs. control (1.52 (95% CI 0.86, 2.67)).

"This is the first study that compares the extent of BMD loss at the lumbar spine and femoral neck in an age and sex matched cohort, and demonstrates that the detrimental effects of coeliac disease are most pronounced in the lower back compared to the hip joint," said Mr Oldroyd of Lancaster University School of Medicine. "These findings may be due to the fact that the bone in the lumbar spine is spongy, less dense and weaker in comparison to the femoral neck, causing it to be more susceptible to the detrimental effects of coeliac disease. There is greater research required to determine why this effect is seen and whether it can have future implications for treatment."

The authors from Lancaster and the Liverpool area collected results of DEXA scans (used to measure BMD) from 1,030 patients with coeliac disease between June 2004 and September 2007. Scan results of the lumbar spine and femoral neck of patients with coeliac disease were compared to a healthy, age and gender matched cohort, with no identifiable risk factors for osteoporosis. Logistic regression analysis was used to investigate the association between coeliac disease and BMD results for the lumbar spine and femoral neck in the lowest tertile of the whole study cohort.

... more about:
»BMD »Lancaster »coeliac disease »risk factor

Abstract Number: THU0142

*BMD refers to the amount of matter per cubic centimeter of bones. Measurements are most commonly made over the lumbar spine and over the upper part of the hip. Average density is around 1500 kg m−3. BMD is often measured with a t-score, the number of standard deviations above or below the mean for a healthy 30 year old adult of the same sex and ethnicity as the patient. Average t-scores are as follows:


Normal: Less than 1 standard deviation (SD) below the young adult reference range (more than -1)

Low bone mass (osteopenia): 1 to 2.5 SDs below the young adult reference range (-1 to -2.5)

Osteoporosis: 2.5 or more SDs below the young adult reference range (-2.5 or less)

Dimple Natali | EurekAlert!
Further information:

Further reports about: BMD Lancaster coeliac disease risk factor

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>