Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Effects of celiac disease on bone mineral density are pronounced in lumbar spine than femoral neck

26.05.2011
Patients with celiac disease are more than 4.5 times more likely to develop osteoporosis compared to healthy people in an age and gender matched cohort with no identifiable risk factors for osteoporosis, according to a study presented today at the EULAR 2011 Annual Congress.

The British study of 1,030 people compares the extent of bone mineral density (BMD)* loss – a common measure of osteoporosis – in two physical locations in the body. The results demonstrated that the mean BMD of the lumbar spine in patients with coeliac disease was significantly different when compared to the control group (1.79 (95% CI 1.32, 2.44)), however not for the femoral neck vs. control (1.52 (95% CI 0.86, 2.67)).

"This is the first study that compares the extent of BMD loss at the lumbar spine and femoral neck in an age and sex matched cohort, and demonstrates that the detrimental effects of coeliac disease are most pronounced in the lower back compared to the hip joint," said Mr Oldroyd of Lancaster University School of Medicine. "These findings may be due to the fact that the bone in the lumbar spine is spongy, less dense and weaker in comparison to the femoral neck, causing it to be more susceptible to the detrimental effects of coeliac disease. There is greater research required to determine why this effect is seen and whether it can have future implications for treatment."

The authors from Lancaster and the Liverpool area collected results of DEXA scans (used to measure BMD) from 1,030 patients with coeliac disease between June 2004 and September 2007. Scan results of the lumbar spine and femoral neck of patients with coeliac disease were compared to a healthy, age and gender matched cohort, with no identifiable risk factors for osteoporosis. Logistic regression analysis was used to investigate the association between coeliac disease and BMD results for the lumbar spine and femoral neck in the lowest tertile of the whole study cohort.

... more about:
»BMD »Lancaster »coeliac disease »risk factor

Abstract Number: THU0142

*BMD refers to the amount of matter per cubic centimeter of bones. Measurements are most commonly made over the lumbar spine and over the upper part of the hip. Average density is around 1500 kg m−3. BMD is often measured with a t-score, the number of standard deviations above or below the mean for a healthy 30 year old adult of the same sex and ethnicity as the patient. Average t-scores are as follows:

T-score

Normal: Less than 1 standard deviation (SD) below the young adult reference range (more than -1)

Low bone mass (osteopenia): 1 to 2.5 SDs below the young adult reference range (-1 to -2.5)

Osteoporosis: 2.5 or more SDs below the young adult reference range (-2.5 or less)

Dimple Natali | EurekAlert!
Further information:
http://www.eular.org

Further reports about: BMD Lancaster coeliac disease risk factor

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>