Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Effect of adenotonsillectomy in children with sleep-disordered breathing

20.12.2011
Children may have a better quality of life (QOL) and diminished cardiovascular disease risk from the decreased endothelin 1 (ET-1) levels after adenotonsillectomy, according to new research published in the December 2011 issue of Otolaryngology – Head and Neck Surgery.

SDB is an increasingly common indication for tonsillectomy and adenoidectomy due to obstructive sleep apnea syndrome (OSAS). Cardiovascular (CV) disease frequently has been reported in patients with moderate to severe OSAS, related abnormalities include: systematic hypertension, pulmonary hypertension with corpulmonale, left ventricular (LV) hypertrophy or dysfunction, cardiac arrhythmias, atherosclerosis, and coronary artery disease.

The study sample included an obstructive sleep apnea survey and a detailed personal and family history. All subjects underwent a complete otolaryngologic examination, otoscopy, and anterior rhinoscopy. Thirty-seven children with a diagnosis of upper airway obstruction caused by adenotonsillar hypertrophy (ATH) were included in the study. Twenty female and 17 male patients, between 3 and 13 years old participated in the study.

Surgical procedures included: 20 tonsillectomies and adenoidectomies (54%), 15 adenoidectomies only (40.6%), and 2 tonsillectomies only (5.4%). Study results show when comparing moderate and severe cases to mild cases according to Brouilette scores, ET-1 levels were significantly higher in moderate and severe cases (P <.01). There was a significant correlation between ET-1 and the OSA-18 survey scale (r =0.442; P =.001).

The objective of the study was to evaluate the influence of adenotonsillectomy on the plasma concentration of ET-1 levels and C-reactive protein (CRP) in children with sleep-disordered breathing (SDB). The primary goal of this research study was to investigate the effect of ATH and adenotonsillectomy on the possible pathogenic mechanisms (endothelial dysfunction and inflammation) that lead to cardiovascular complications.

Based on the study findings, the authors indicate: "…that children with SDB who undergo adenotonsillectomy may have a better QOL, and the positive influence of adenotonsillectomy on CV function might be mediated by the decrease in ET-1 levels." The study's authors acknowledge that more research is needed, noting: "Further studies with longer follow-up and a larger population sample are warranted to demonstrate the association between SDB due to ATH and ET-1 levels and to confirm the influence of adenotonsillectomy on ET-1 and CRP levels to prevent cardiovascular disease in children."

Otolaryngology – Head and Neck Surgery is the official scientific journal of the American Academy of Otolaryngology – Head and Neck Surgery Foundation (AAO-HNSF). The study's authors are Arzu Tatlipinar, Burak Cimen, Dursun Duman, Erkan Esen, Sema Koksal and Tanju Gökçeer.

Reporters who wish to obtain a copy of the study, "Effect of Adenotonsillectomy on Endothelin-1 and C-Reactive Protein Levels in Children with Sleep-Disordered Breathing" should contact Mary Stewart at 1-703-535-3762, or newsroom@entnet.org.

About the AAO-HNS

The American Academy of Otolaryngology – Head and Neck Surgery (http://www.entnet.org), one of the oldest medical associations in the nation, represents nearly 12,000 physicians and allied health professionals who specialize in the diagnosis and treatment of disorders of the ears, nose, throat, and related structures of the head and neck. The Academy serves its members by facilitating the advancement of the science and art of medicine related to otolaryngology and by representing the specialty in governmental and socioeconomic issues. The organization's vision: "Empowering otolaryngologist-head and neck surgeons to deliver the best patient care."

Mary Stewart | EurekAlert!
Further information:
http://www.entnet.org

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>